SAB4200439
Anti-EXOSC5 (N-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-Exosome component 5, p12B, Anti-RRP41B, Anti-RRP46, Anti-Rrp46p, Anti-hRrp46p
登录 查看组织和合同定价。
选择尺寸
关于此项目
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~25 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 1-2 μg using lysates of human HeLa cells., indirect immunofluorescence: 1-2 μg/mL using human HeLa cells., western blot: 1-2 μg/mL using whole extracts of human HEK-293T cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EXOSC5(56915)
General description
Exosome component 5 (EXOSC5) protein is a non-catalytic element of the RNA exosome complex in eukaryotes. The EXOSC5 gene is located on the human chromosome at 19q13.2.
Immunogen
peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. The antibody is affinity-purified using the immunizing peptide immobilized on agarose.
Application
Anti-EXOSC5 (N-terminal) antibody produced in rabbit may be used in:
- immunoblotting
- immunoprecipitation
- immunofluorescence
Biochem/physiol Actions
Anti-EXOSC5 (N-terminal) recognizes human EXOSC5.
Exosome component 5 (EXOSC5) plays a role in the processing and degradation of RNA. This protein also plays a role in cleaving the DNA during apoptosis. EXOSC5 possesses a 3′-5′ exoribonuclease activity. Overexpression of the EXOSC5 gene is associated with several cancers such as melanoma, prostate, colorectal and lung cancer.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8°C for up to one month. Forextended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Hongda Pan et al.
Frontiers in oncology, 9, 643-643 (2019-08-06)
Background and Objective: Exosome component 5 (EXOSC5) is a novel cancer-related gene that is aberrantly expressed in various malignances. However, the molecular mechanism and biological role of EXOSC5 have not been explored in colorectal cancer (CRC). In this study, we
Jillian de Wilde et al.
International journal of cancer, 122(4), 877-888 (2007-10-26)
Although high-risk human papillomavirus (HPV) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. One key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit
相关内容
Instructions
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持