biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~100 kDa
species reactivity
human, rat, mouse
concentration
~1.0 mg/mL
technique(s)
western blot: 2-4 μg/mL using whole extracts of HEK-293T cells overexpressing human COG5.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COG5(10466)
mouse ... Cog5(238123)
rat ... Cog5(298945)
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General description
Conserved oligomeric Golgi complex 5 (COG5), also known as CDG2I, GTC90 and GOLTC1, is a member of the conserved oligomeric Golgi (COG) complex. The complex is an evolutionarily conserved multisubunit protein COG complex. COG is composed of eight distinct subunits organized in two heterotrimeric groups, Cog2-Cog3-Cog4 and Cog5-Cog6-Cog7, which are linked by the dimeric group formed by Cog1 and Cog8.
Immunogen
peptide corresponding to the C-terminal region of human COG5, conjugated to KLH. The corresponding sequence is identical in mouse, rat, canine and monkey COG5.
Application
Anti-COG5 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
Conserved Oligomeric Golgi complex 5 (COG5) complex that regulates membrane trafficking and maintenance of Golgi glycosylation machinery in eukaryotic cells. Mutations in COG5 gene result in congenital disorder of glycosylation type 2I.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Conserved oligomeric Golgi complex specifically regulates the maintenance of Golgi glycosylation machinery
Pokrovskaya ID, et al.
Glycobiology, 21(12), 1554-1569 (2011)
COG5 variants lead to complex early onset retinal degeneration, upregulation of PERK and DNA damage.
Sami Tabbarah et al.
Scientific reports, 10(1), 21269-21269 (2020-12-06)
Leber congenital amaurosis (LCA), a form of autosomal recessive severe early-onset retinal degeneration, is an important cause of childhood blindness. This may be associated with systemic features or not. Here we identified COG5 compound-heterozygous variants in patients affected with a
Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates
Quental R, et al.
BMC Evolutionary Biology, 10(1), 212-212 (2010)
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|---|---|
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