SAB4200451
Anti-NMD3 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-60S Ribosomal export protein NMD3, Anti-CGI-07, Anti-NMD3 homolog (S. cerevisiae)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~58 kDa
species reactivity
human, rat, mouse
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 2.5-5 μg/mL using human HeLa cells., western blot: 2.5-5.0 μg/mL using whole extracts of HEK-293T cells over-expressing mouse NMD3.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NMD3(51068)
mouse ... Nmd3(97112)
rat ... Nmd3(310512)
General description
NMD3 ribosome export adaptor (NMD3) is an adaptor for 60S subunit export via the export receptor CRM1 (XPO1). In human, the C-terminal domain of NMD3 comprises a CRM1- dependent leucine-rich nuclear export signal (NES) and a nuclear localization signal (NLS) in its. Two zinc-binding centres and the ribosome-binding domain forms the N-terminal domain.
Immunogen
peptide corresponding to an internal region of human NMD3, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine and dog.
Application
Anti-NMD3 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
NMD3 ribosome export adaptor (NMD3) is a highly conserved nucleocytoplasmic shuttling protein, essential for nuclear export of 60S ribosomal subunits.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Characterization of the nuclear export adaptor protein Nmd3 in association with the 60S ribosomal subunit
Sengupta J, et al.
The Journal of Cell Biology, 189(7), 1079-1086 (2010)
Coordinated nuclear export of 60S ribosomal subunits and NMD3 in vertebrates
Trotta CR, et al.
The Embo Journal, 22(11), 2841-2851 (2003)
Baoyan Bai et al.
Nucleus (Austin, Tex.), 4(4), 315-325 (2013-06-21)
CRM1 is an export factor that together with its adaptor NMD3 transports numerous cargo molecules from the nucleus to cytoplasm through the nuclear pore. Previous studies have suggested that CRM1 and NMD3 are detected in the nucleolus. However, their localization
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