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Merck
CN

SAB4200461

Sigma-Aldrich

Anti-Arc (N-terminal) antibody produced in rabbit

enhanced validation

~1.0 mg/mL, affinity isolated antibody

别名:

Anti-Activity-regulated cytoskeleton-associated protein, Anti-Arc3.1, Anti-Arg3.1

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41

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生物来源

rabbit

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

antigen ~55 kDa

种属反应性

rat, human

增强验证

recombinant expression
Learn more about Antibody Enhanced Validation

浓度

~1.0 mg/mL

技术

immunohistochemistry: 20-30 μg/mL using formalin-fixed, paraffin-embedded rat brain.
immunoprecipitation (IP): 2-4 μg using lysates of HEK-293T cells over-expressing human Arc.
western blot: 1.5-3.0 μg/mL using extracts of HEK-293T cells over-expressing human Arc.

UniProt登记号

Q7LC44

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... ARC(23237)
rat ... Arc(54323)

一般描述

Activity-regulated cytoskeleton-associated protein (Arc) is a growth factor and immediate-early gene (IEG) that is enriched in the brain. Arc is located in the distal dendrites and spine. The Arc gene is located on the human chromosome at 8q24.3.

免疫原

synthetic peptide corresponding to a sequence at the N-terminal region of human Arc, conjugated to KLH. The corresponding sequence is highly conserved (90% sequence identity) in rat and mouse Arc.

应用

Anti-Arc (N-terminal) antibody produced in rabbit may be used in:
  • immunoblotting
  • immunoprecipitation
  • immunohistochemistry

生化/生理作用

Activity-regulated cytoskeleton-associated protein (Arc) induction is required for late long-term potentiation (LTP) and memory consolidation. It also plays a role in LTP-induced cofilin phosphorylation and F-actin stabilization. This protein affects synaptic plasticity. Arc regulates the endocytosis of α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors through its interaction with endocytic proteins endophilin2/3 and dynamin. It is associated with notch signaling and spine morphology.
Anti-Arc(N-terminal) specifically recognizes humanand rat Arc.

外形

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

制备说明

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution bycentrifugation before use. Working dilutions should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
052M4767

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