SAB4200469
Anti-POLR2A antibody produced in rabbit
Ig fraction of antiserum
别名:
Anti-POLR2, Anti-POLRA, Anti-RPBh1, Anti-RPO2, Anti-RPOL2, Anti-RpIILS, Anti-hRPB220, Anti-hsRPB1, Anti-polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, RPB1
生物来源
rabbit
偶联物
unconjugated
抗体形式
Ig fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~250 kDa
种属反应性
human
技术
immunoprecipitation (IP): 5-10 μL using whole extract of human HeLa cells
indirect immunofluorescence: 1:400-1:800 using human HeLa cells
western blot: 1:2000-1:4000 using nuclear extracts of HeLa cells
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... POLR2A(5430)
mouse ... Polr2a(20020)
rat ... Polr2a(363633)
一般描述
RNA polymerase II subunit A (POLR2A) gene with 29 exons is mapped on human chromosome 17p13.1. This gene codes for a catalytic subunit of RNA polymerase II. The encoded protein consists of a highly conserved 5′ flanking region.
免疫原
peptide corresponding to the N-terminal region of human POLR2A, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine, dog and pig.
生化/生理作用
RNA polymerase II subunit A (POLR2A) catalyzes the synthesis of messenger RNA in eukaryotes. The 5′ flanking domain of RNA polymerase II subunit A (POLR2A) plays a vital role in transcriptional regulation. Mutation in the gene is associated with the pathogenesis of meningiomas.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Pol?), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver
Brauze D
Environmental Toxicology and Pharmacology, 34, 819-825 (2012)
The human gene encoding the largest subunit of RNA polymerase II
Mita K
Gene, 159, 285-286 (1995)
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Clark VE
Nature Genetics, 48, 1253-1259 (2016)
1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells.
Wang J
Oncology Reports, 19, 1155-1164 (2008)
Farhana Taher Sumya et al.
Traffic (Copenhagen, Denmark), 24(2), 52-75 (2022-12-06)
Conserved Oligomeric Golgi (COG) complex controls Golgi trafficking and glycosylation, but the precise COG mechanism is unknown. The auxin-inducible acute degradation system was employed to investigate initial defects resulting from COG dysfunction. We found that acute COG inactivation caused a
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