SAB4200469
Anti-POLR2A antibody produced in rabbit
Ig fraction of antiserum
别名:
Anti-POLR2, Anti-POLRA, Anti-RPBh1, Anti-RPO2, Anti-RPOL2, Anti-RpIILS, Anti-hRPB220, Anti-hsRPB1, Anti-polymerase (RNA) II (DNA directed) polypeptide A, 220kDa, RPB1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IP, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
Ig fraction of antiserum
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~250 kDa
species reactivity
human
technique(s)
immunoprecipitation (IP): 5-10 μL using whole extract of human HeLa cells, indirect immunofluorescence: 1:400-1:800 using human HeLa cells, western blot: 1:2000-1:4000 using nuclear extracts of HeLa cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... POLR2A(5430)
mouse ... Polr2a(20020)
rat ... Polr2a(363633)
General description
RNA polymerase II subunit A (POLR2A) gene with 29 exons is mapped on human chromosome 17p13.1. This gene codes for a catalytic subunit of RNA polymerase II. The encoded protein consists of a highly conserved 5′ flanking region.
Immunogen
peptide corresponding to the N-terminal region of human POLR2A, conjugated to KLH. The corresponding sequence is identical in mouse, rat, monkey, bovine, dog and pig.
Biochem/physiol Actions
RNA polymerase II subunit A (POLR2A) catalyzes the synthesis of messenger RNA in eukaryotes. The 5′ flanking domain of RNA polymerase II subunit A (POLR2A) plays a vital role in transcriptional regulation. Mutation in the gene is associated with the pathogenesis of meningiomas.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The human gene encoding the largest subunit of RNA polymerase II
Mita K
Gene, 159, 285-286 (1995)
The effect of aryl hydrocarbon receptor ligands on the expression of polymerase (DNA directed) kappa (Pol?), polymerase RNA II (DNA directed) polypeptide A (PolR2a), CYP1B1 and CYP1A1 genes in rat liver
Brauze D
Environmental Toxicology and Pharmacology, 34, 819-825 (2012)
Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas
Clark VE
Nature Genetics, 48, 1253-1259 (2016)
1p31, 7q21 and 18q21 chromosomal aberrations and candidate genes in acquired vinblastine resistance of human cervical carcinoma KB cells.
Wang J
Oncology Reports, 19, 1155-1164 (2008)
Farhana Taher Sumya et al.
Traffic (Copenhagen, Denmark), 24(2), 52-75 (2022-12-06)
Conserved Oligomeric Golgi (COG) complex controls Golgi trafficking and glycosylation, but the precise COG mechanism is unknown. The auxin-inducible acute degradation system was employed to investigate initial defects resulting from COG dysfunction. We found that acute COG inactivation caused a
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