Anti-ADAR1 antibody, Mouse monoclonal

Monoclonal Anti-ADAR1 (mouse IgG3 isotype) is derived from the hybridoma ADAR61 produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Adenosine deaminase that acts in RNA 1 (ADAR1) and ADAR2 are expressed in most tissues but in general, the pre-mRNA being edited represents receptors of the central nervous systems. ADAR1 has several isoforms which include ADAR1 (150kDa) and two short isoforms (80 and 110 kDa) that are functional.

a peptide corresponding to a sequence at the C-terminus of human ADAR, conjugated to KLH.

Monoclonal Anti-ADAR1 antibody produced in mouse has been used in:

• immunoblotting
• immunoprecipitation
• flow cytometry

RNA editing by hydrolytic deamination of adenosine (A) to inosine (I) in double-stranded (ds)RNA is the most common type of editing in higher eukaryotes. This RNA editing event is catalyzed by the adenosine deaminase that acts in RNA (ADAR) enzyme. Two ADAR enzymes have been shown to possess enzymatic activity in mammals, ADAR1 and ADAR2. Both can convert specific adenosine to inosine in pre-mRNA and can also convert up to 40-50% of the adenosines in long synthetic duplex RNAs. ADAR1 plays critical roles in differentiating cells of embryo and adult tissues, supporting cell survival and permitting their further differentiation and maturation. Its role in embryonic development is especially demonstrated within the hematopoietic lineage as well as in adult hematopoietic progenitor cells (HPCs). ADAR1 is also an essential regulator of hematopoietic stem cell maintenance and suppressor of interferon signaling that may protect organisms from the deleterious effects of interferon activation associated with many pathological processes, including chronic inflammation, autoimmune disorders and cancer.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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