Anti-Adrenomedullin antibody produced in rabbit

Adrenomedullin (ADM) is initially extracted from human pheochromocytoma. It is a member of the amylin/calcitonin gene-related peptide (CGRP) super-family. ADM is broadly distributed in many tissues during development and adulthood. It is most highly expressed in endothelial cells and vascular smooth muscle cells and is localized in highly vascularized tissues including the kidney, intestine, stomach, brain, lung, heart and placenta. The ADM gene is mapped to the human chromosome location 11p15.4.

synthetic peptide corresponding to a sequence at the C-terminus of human adrenomedullin (ADM), conjugated to KLH. The corresponding sequence is highly conserved in rat and mouse ADM (83% sequence identity).

Anti-Adrenomedullin antibody produced in rabbit is suitable for use in immunohistochemistry and enzyme-linked immunosorbent assay (ELISA).

Adrenomedullin (ADM) exhibits a wide range of biological actions including vasorelaxant, diuretic, and cardiotonic effects. It blocks adipocyte differentiation and regulates glucose metabolism. ADM is a potent hypotensive and vasodilatory peptide. It modulates hormone release, natriuresis and antimicrobial effects. This circulating peptide also regulates the proliferation, migration and differentiation of various cell types. ADM plays a significant role in angiogenesis and pathological conditions including cardiovascular disease, ischemia and carcinogenesis. Productions of ADM are controlled by oxidative stress and inflammation-related substances like lipopolysaccharide and inflammatory cytokines. ADM and pro adrenomedullin N-terminal 20 peptide (PAMP) are derived from the same precursor pro adrenomedullin, by proteolytic processing. It exerts its effects via G-protein coupled calcitonin-like receptors (CRLR) complexed with either receptor activity-modifying protein-2 (RAMP2) or RAMP3.

Anti-Adrenomedullin specifically recognizes human ADM.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

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