SAB4200518
Anti-SLC1A1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-EAAT3, Anti-solute carrier family 1, member 1, EAAC1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~70 kDa
species reactivity
mouse, human
enhanced validation
recombinant expression
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concentration
~1.0 mg/mL
technique(s)
immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded human small intestine., western blot: 1.5-3.0 μg/mL using Neuro-2a cell extracts.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SLC1A1(6505)
mouse ... Slc1a1(20510)
rat ... Slc1a1(25550)
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General description
SLC1A1 (also known as EAAC1, EAAT3) is localized at the postsynaptic site of neurons. It is expressed at moderate levels in the adult brain, mainly in the hippocampus, basal ganglia and olfactory bulb and is considered to make a minor contribution to glutamate removal from the synapse.
Immunogen
synthetic peptide corresponding to a sequence near the C-terminus of human SLC1A1, conjugated to KLH. The corresponding sequence is identical in mouse and rat SLC1A1.
Application
Anti-SLC1A1 antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.
Biochem/physiol Actions
SLC1A1 regulates the developmental effects of glutamate. It is highly regulated by neural activity and intracellular signaling pathways involving mainly PKCa, PI3K, and glial factors, resulting in rapid changes in the trafficking of the transporter and in its membrane location.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Plasma membrane expression of the neuronal glutamate transporter EAAC1 is regulated by glial factors: evidence for different regulatory pathways associated with neuronal maturation
Lortet S, et al.
Neurochemistry International, 52(7), 1373-1382 (2008)
The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?
Nieoullon A, et al.
Journal of Neurochemistry, 98(4), 1007-1018 (2006)
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