SAB4200518
Anti-SLC1A1 antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-EAAT3, Anti-solute carrier family 1, member 1, EAAC1
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~70 kDa
种属反应性
mouse, human
增强验证
recombinant expression
Learn more about Antibody Enhanced Validation
浓度
~1.0 mg/mL
技术
immunohistochemistry: 10-20 μg/mL using formalin-fixed paraffin-embedded human small intestine.
western blot: 1.5-3.0 μg/mL using Neuro-2a cell extracts.
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SLC1A1(6505)
mouse ... Slc1a1(20510)
rat ... Slc1a1(25550)
一般描述
SLC1A1 (also known as EAAC1, EAAT3) is localized at the postsynaptic site of neurons. It is expressed at moderate levels in the adult brain, mainly in the hippocampus, basal ganglia and olfactory bulb and is considered to make a minor contribution to glutamate removal from the synapse.
免疫原
synthetic peptide corresponding to a sequence near the C-terminus of human SLC1A1, conjugated to KLH. The corresponding sequence is identical in mouse and rat SLC1A1.
应用
Anti-SLC1A1 antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.
生化/生理作用
SLC1A1 regulates the developmental effects of glutamate. It is highly regulated by neural activity and intracellular signaling pathways involving mainly PKCa, PI3K, and glial factors, resulting in rapid changes in the trafficking of the transporter and in its membrane location.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
The neuronal excitatory amino acid transporter EAAC1/EAAT3: does it represent a major actor at the brain excitatory synapse?
Nieoullon A, et al.
Journal of Neurochemistry, 98(4), 1007-1018 (2006)
Plasma membrane expression of the neuronal glutamate transporter EAAC1 is regulated by glial factors: evidence for different regulatory pathways associated with neuronal maturation
Lortet S, et al.
Neurochemistry International, 52(7), 1373-1382 (2008)
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