SAB4200550
Anti-Strumpellin (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-WASH complex subunit strumpellin
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
3
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~110 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoprecipitation (IP): 5-10 μg using lysates of human DU-145 cells., western blot: 5-10 μg/mL using whole extracts of human PC-3 cells.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KIAA0196(9897)
mouse ... E430025E21Rik(223593)
General description
Strumpellin is a component of the Wiskott−Aldrich syndrome protein and scar homolog (WASH) multiprotein complex. It is encoded by Wiskott−Aldrich syndrome protein and scar homolog complex subunit 5 (WASHC5) gene. WASHC5 gene is located on the human chromosome at 8q24.13.
Immunogen
synthetic peptide corresponding to the C-terminal region of human Strumpellin, conjugated to KLH. The corresponding sequence is identical in mouse and rat.
Application
Anti-Strumpellin (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Anti-Strumpellin (C-terminal) recognizes human Strumpellin.
Strumpellin being a component of Wiskott−Aldrich syndrome protein and scar homolog complex (WASH) multiprotein complexis involved in regulating actin. Mutations in the gene encoding strumpellin, KIAA0196 is associated with hereditary spastic paraplegia, a progressive neurodegenerative disorder. Strumpellin is present in protein aggregate diseases affecting striated muscles and the central nervous system (CNS).
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °Cfor up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog, our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Strumpellin is a novel valosin-containing protein binding partner linking hereditary spastic paraplegia to protein aggregation diseases
Clemen C S, et al.
Brain, 133(10), 2920-2941 (2010)
The hereditary spastic paraplegia protein strumpellin: characterisation in neurons and of the effect of disease mutations on WASH complex assembly and function
Freeman C, et al.
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1832(1), 160-173 (2013)
Identification of KIAA0196 as a novel susceptibility gene for myofibril structural disorganization in cardiac development
Bu H, et al.
International Journal of Cardiology, 133(10), 2920-2941 (2020)
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