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Merck
CN

SAB4200562

Sigma-Aldrich

Anti-AOX1 antibody, Mouse monoclonal

clone AO15, purified from hybridoma cell culture

别名:

Monoclonal Anti-AO, Monoclonal Anti-AOH1, Monoclonal Anti-AOX1 antibody produced in mouse, Monoclonal Anti-EC 1.2.3.1, Monoclonal Anti-aldehyde oxidase 1

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UNSPSC代码:
12352203
NACRES:
NA.41
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生物来源

mouse

偶联物

unconjugated

抗体形式

purified from hybridoma cell culture

抗体产品类型

primary antibodies

克隆

AO15, monoclonal

表单

buffered aqueous solution

分子量

antigen ~148 kDa

种属反应性

human

浓度

~1 mg/mL

技术

western blot: 1.0-2.0 μg/mL using extracts of HepG2 cells.

同位素/亚型

IgG1

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... AOX1(316)

一般描述

Monoclonal Anti-AOX1 (mouse IgG1 isotype) is derived from the hybridoma AO15 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. Aldehyde oxidase 1 (AOX1) comprises the 2Fe/2S clusters and two flavin adenine nucleotide (FAD) domain-containing N-terminal domain I and II, respectively. The C-terminal domain encompasses domain III with a substrate-binding site. The gene encoding AOX1 is mapped to human chromosome 2q33.1.

免疫原

synthetic peptide corresponding to an internal sequence of human AOX1. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

应用

Monoclonal Anti-AOX1 antibody produced in mouse has been used in reverse-phase protein array analysis(5) and immunoblotting.

生化/生理作用

Aldehyde oxidase 1 (AOX1), along with the endoplasmic cytochrome P450 system (CYP450), participates in the drug metabolism and generation of reactive oxygen species. It also has a role in the hepatic phase I metabolism of numerous xenobiotics. Reduced AOX1 protein expression is implicated in chronic pancreatitis, and hepatocellular carcinoma. Furthermore, hypermethylation of the AOX1 promoter region is observed in colon cancer and prostate cancer, making it a potential biomarker for prostate cancer diagnosis. Polymorphism in the AOX1 gene also displays variation in metabolism of the quinoxaline phenoxypropionic acid derivative XK469.
Monoclonal Anti-AOX1 recognizes human AOX1.

外形

0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。

制备说明

For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,isnot recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

A pharmacogenetic study of aldehyde oxidase I in patients treated with XK469
Ramirez J, et al.
Pharmacogenetics and Genomics, 24(2), 129-129 (2014)
The role of aldehyde oxidase in drug metabolism
Garattini E and Terao M
Expert Opinion on Drug Metabolism & Toxicology, 8(4), 487-503 (2013)
Identification of new differentially methylated genes that have potential functional consequences in prostate cancer
Kim JW, et al.
Testing, 7(10), e48455-e48455 (2012)
Kalpana D Acharya et al.
eNeuro, 4(5) (2017-09-29)
Progestins bind to the progestin receptor (PR) isoforms, PR-A and PR-B, in brain to influence development, female reproduction, anxiety, and stress. Hormone-activated PRs associate with multiple proteins to form functional complexes. In the present study, proteins from female mouse hypothalamus

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