抗-COG4 兔抗

Conserved oligomeric Golgi complex 4 (COG4) is a member of the conserved oligomeric Golgi (COG) complex. COG complex comprises eight distinct subunits Cog2-Cog3- Cog4 (lobe A) and Cog5-Cog6-Cog7 (lobe B). These two heterotrimeric groups are linked by the dimeric group formed by Cog1 and Cog8. COG4 gene is mapped to human chromosome 16q22.1.

peptide corresponding to an internal region of human COG4, conjugated to KLH. The corresponding sequence is identical in mouse, rat, dog and monkey COG4.

Anti-COG4 antibody produced in rabbit may be used in immunoblotting and immunofluorescence.

Anti-COG4 recognizes human and rat COG4.

Conserved oligomeric Golgi complex 4 (COG4) is needed for normal Golgi function. COG4 is implicated in Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) pairing. It is also and Golgi-to-endoplasmic reticulum (ER) retrograde transport via its interaction with the suppressor of loss of YPT1 protein 1 (Sly1). Defects in the COG4 gene is implicated congenital disorder of glycosylation type II (CDG-II). Mutation in the COG4 gene is also implicated in Saul-Wilson syndrome with vesicular trafficking disruption.

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage,clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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