SAB4200569
Anti-COG4 (C-terminal) antibody produced in rabbit
~1.0 mg/mL, affinity isolated antibody
别名:
Anti-CDG2J, Anti-COD1, Anti-COG complex subunit 4, Anti-COMPONENT OF OLIGOMERIC GOLGI COMPLEX 4
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~84 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
indirect immunofluorescence: 2.5-5.0 μg/mL using human HeLa cells., western blot: 2.5-5.0 μg/mL using whole extracts of hamster CHO cells.
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... COG4(25839)
General description
Conserved oligomeric Golgi complex 4 (COG4) is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG4 gene is mapped on the human chromosome at 16q22.1.
Immunogen
peptide corresponding to the C-terminal region of human COG4, conjugated to KLH. The corresponding sequence is identical in bovine, dog and monkey, and differs by one amino acid in rat and mouse COG4.
Application
Anti-COG4 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunofluorescence.
Biochem/physiol Actions
Anti-COG4 recognizes human and hamster COG4.
Conserved oligomeric Golgi complex 4 (COG4) is needed for normal Golgi function. It is implicated in Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) pairing and Golgi-to-endoplasmic reticulum (ER) retrograde transport via its interaction with the Sec1/Munc18 (SM) protein Sly1. Defects in the COG4 gene may be a cause of congenital disorder of glycosylation type II (CDG2).
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review
Norton P A and Mehta A S
World Journal of Gastroenterology, 25(23), 2947-2947 (2019)
Direct interaction between the COG complex and the SM protein, Sly1, is required for Golgi SNARE pairing
Laufman O, et al.
The Embo Journal, 28(14), 2006-2017 (2009)
Structural basis for a human glycosylation disorder caused by mutation of the COG4 gene
Richardson B C, et al.
Proceedings of the National Academy of Sciences, 106(32), 13329-13334 (2009)
Comparative analyses of the Conserved Oligomeric Golgi (COG) complex in vertebrates
Quental R, et al.
BMC Evolutionary Biology, 10(1), 212-212 (2010)
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