Anti-COG4 (C-terminal) antibody produced in rabbit

Conserved oligomeric Golgi complex 4 (COG4) is a member of the conserved oligomeric Golgi (COG) complex. COG complex is an evolutionarily conserved multi-subunit protein complex. COG4 gene is mapped on the human chromosome at 16q22.1.

peptide corresponding to the C-terminal region of human COG4, conjugated to KLH. The corresponding sequence is identical in bovine, dog and monkey, and differs by one amino acid in rat and mouse COG4.

Anti-COG4 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunofluorescence.

Anti-COG4 recognizes human and hamster COG4.

Conserved oligomeric Golgi complex 4 (COG4) is needed for normal Golgi function. It is implicated in Golgi soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) pairing and Golgi-to-endoplasmic reticulum (ER) retrograde transport via its interaction with the Sec1/Munc18 (SM) protein Sly1. Defects in the COG4 gene may be a cause of congenital disorder of glycosylation type II (CDG2).

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.

For continuous use, store at 2-8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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