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Merck
CN

SAB4200599

Monoclonal Anti-SORBS1 antibody produced in mouse

~1.0 mg/mL, clone SORBS-437, purified immunoglobulin

别名:

Monoclonal Anti-2310065E01RIK, Monoclonal Anti-9530001P15Rik, Monoclonal Anti-CAP, Monoclonal Anti-DKFZp451C066, Monoclonal Anti-DKFZp586P1422, Monoclonal Anti-FLAF2, Monoclonal Anti-FLJ12406, Monoclonal Anti-KIAA1296, Monoclonal Anti-LOC678826, Monoclonal Anti-Ponsin, Monoclonal Anti-R85FL, Monoclonal Anti-RP11-476E15.1, Monoclonal Anti-SH3D5, Monoclonal Anti-SH3P12, Monoclonal Anti-SORB1, Monoclonal Anti-SORBS1, Monoclonal Anti-c-Cbl associated, Monoclonal Anti-mKIAA1296, Monoclonal Anti-sorbin and SH3 domain containing 1

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352209
Conjugate:
unconjugated
Clone:
SORBS-437, monoclonal
Application:
FACS
Citations:
8

主要文件

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

SORBS-437, monoclonal

form

buffered aqueous solution

mol wt

antigen ~95 kDa

species reactivity

human, rat, mouse

concentration

~1.0 mg/mL

technique(s)

flow cytometry: 10-20 μg/test using HeLa cells, immunoblotting: 0.25-0.5 μg/mL using Caco-2 total cell extracts

isotype

IgG1

UniProt accession no.

Q9BX66

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SORBS1(10580)

General description

Monoclonal Anti-SORBS1 (mouse IgG1 isotype) is derived from the hybridoma SORBS-437 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. SORBS1 is an adaptor protein and is mainly expressed in insulin-sensitive tissues such as adipose tissue, liver and skeletal muscle.
Sorbin and SH3 domain-containing protein 1 (SORBS1) is also called c-Cbl-associated protein (CAP) or ponsin. The SORBS1 gene is located on human chromosome 10q24.1. SORBS1 has sorbin homology domain (SOHO) and three SH3 (sarcomahomology 3) domains.

Immunogen

Synthetic peptide corresponding to an internal sequence of human SORBS1. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

Application

Monoclonal Anti-SORBS1 antibody produced in mouse may be used in immunoblotting and flow cytometry.

Biochem/physiol Actions

Monoclonal Anti-SORBS1 recognizes human, rat and mouse SORBS1.
SORBS1 acts as an insulin-signaling molecule by forming a complex with the oncoprotein Cbl.
Sorbin and SH3 domain-containing protein 1 (SORBS1) modulates cell adhesion by interacting with cytoskeletal proteins. It regulates glucose uptake. Polymorphisms in SORBS1 is implicated in obesity, insulin resistance, type 2 diabetes and diabetic nephropathy. It suppresses tumorigenesis by modulating c-Jun N-terminal kinases (JNKs) of mitogen-activated protein kinase (MAPK) signaling pathway in lung and breast cancers.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For extended storage, freeze at -20 0C in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000157454
0000148883
0000148883
063M4770V

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Molecular scanning of the human sorbin and SH3-domain-containing-1 (SORBS1) gene: positive association of the T228A polymorphism with obesity and type 2 diabetes
Lin WH, et al.
Human Molecular Genetics, 10(17), 1753-1760 (2001)
Cloning, mapping, and characterization of the human sorbin and SH3 domain containing 1 (SORBS1) gene: a protein associated with c-Abl during insulin signaling in the hepatoma cell line Hep3B
Lin WH, et al.
Genomics, 74(1), 12-20 (2001)
SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome-wide association study in patients with type 1 diabetes
Germain M, et al.
Diabetologia, 58(3), 543-548 (2015)
Wei-Shiung Yang et al.
Obesity research, 11(4), 586-590 (2003-04-12)
The SORBS1 gene has been shown to be an important adaptor protein in the insulin-signaling pathway in many molecular and cellular biology studies. However, its roles in humans either in health or disease are rarely explored. In this report, we
CAP defines a second signalling pathway required for insulin-stimulated glucose transport
Baumann C, et al.
Nature, 407(6801), 202-202 (2000)
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