SAB4200600
Monoclonal Anti-KHSRP antibody produced in mouse
clone KS-8, purified immunoglobulin
别名:
Anti-6330409F21Rik, Anti-FUBP2, Anti-FBP2, Anti-KH-type splicing regulatory protein, Anti-KHSRP, Anti-KSRP, Anti-MARTA1, Anti-MGC99676
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Clone:
KS-8, monoclonal
Species reactivity:
rat, mouse, human, chicken, bovine, canine, hamster
Application:
FACS, ICC, IF
Citations:
3
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
KS-8, monoclonal
form
buffered aqueous solution
mol wt
antigen ~82 kDa
species reactivity
rat, mouse, human, chicken, bovine, canine, hamster
concentration
~1.0 mg/mL
technique(s)
flow cytometry: 2-4 μg/test using HEK-293T cells, immunoblotting: 0.25-0.5 μg/mL using HEK-293T total cell extracts, immunocytochemistry: suitable, immunofluorescence: 2.5-5 μg/mL using HEK-293T cells
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KHSRP(8570)
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General description
Monoclonal Anti-KHSRP (mouse IgG1 isotype) is derived from the hybridoma KS-8 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide. K homology type-splicing regulatory protein (KHSRP) is an nucleic acid binding protein. It is localized in the cytoplasm and nucleus of the cell. It contains four K homology RNA-binding domains, two N- and C-terminals and protein interaction motifs. KHSRP gene is located on the human chromosome at 19p13.3.
Immunogen
synthetic peptide corresponding to an internal sequence of human KHSRP
Application
Monoclonal Anti-KHSRP antibody produced in mouse may be used in:
- immunoblotting
- immunocytochemistry
- flow cytometry
- immunofluorescence
Biochem/physiol Actions
K homology type-splicing regulatory protein (KHSRP) acts as a transcription factor that affects RNA fates at multiple levels including mRNA decay and alternative pre-mRNA splicing. It is involved in rapid decay of AU-rich element (ARE)-containing mRNAs and maturation of microRNAs (miRNAs). KHSRP is significantly modulated in response to breast cancer type 1 (BRCA1) expression, suggesting this factor may contribute to the BRCA1-associated tumor phenotype.
Monoclonal Anti- KHSRP recognizes human, cow, chicken, dog, hamster, rat and mouse KHSRP.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium.
Preparation Note
For extended storage, freeze at -20 °C in working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Functional and molecular insights into KSRP function in mRNA decay
Briata P, et al.
Biochimica et biophysica acta. Gene regulatory mechanisms, 1829(6-7), 689-694 (2013)
BRCA1 modulates the expression of hnRNPA2B1 and KHSRP
Santarosa M, et al.
Cell Cycle, 9(23), 4666-4673 (2010)
Mapping of theKHSRPGene to a Region of Conserved Synteny on Human Chromosome 19p13. 3 and Mouse Chromosome 17
Ring H Z, et al.
Genomics, 56(3), 350-352 (1999)
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