SAB4200607
Anti-Claudin-3 antibody produced in rabbit
affinity isolated antibody
别名:
Cldn3, Rat ventral prostate 1 protein (RVP1)
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Species reactivity:
human, rat
Technique(s):
immunoblotting: 1-2 μg/mL using A549 cells extracts, immunohistochemistry: 5-10 μg/mL using formalin-fixed, paraffin-embedded rat intestine/duodenum sections
Application:
IHC
Citations:
6
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
form
buffered aqueous solution
species reactivity
human, rat
concentration
~1 mg/mL
technique(s)
immunoblotting: 1-2 μg/mL using A549 cells extracts, immunohistochemistry: 5-10 μg/mL using formalin-fixed, paraffin-embedded rat intestine/duodenum sections
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CLDN3(1365)
rat ... Cldn3(65130)
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General description
Claudin-3 (CLDN3) is located on the human chromosome at 7q11.23.
Immunogen
a synthetic peptide corresponding to an internal sequence of rat Caludin-3, conjugated to KLH
Application
Anti-Claudin-3 antibody produced in rabbit may be used in:
- immunoblotting
- immunohistochemistry
- immunofluorescence
Biochem/physiol Actions
Anti-Claudin-3 recognizes human and rat Claudin-3.
Claudin-3 (CLDN3) promotes interactions with other cells in vivo that prevent growth and metastatic potential by assisting the expression of E-cadherin and limiting β-catenin signaling. CLDN3 represents a promising target for cancer detection, diagnosis and therapy. Overexpression of CLDN3 is associated with several neoplasias, such as ovarian, breast, prostate and pancreatic cancers. CLDN3 levels are increased in lung adenocarcinoma cells.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Williams syndrome deficits in visual spatial processing linked to GTF2IRD1 and GTF2I on chromosome 7q11. 23
Hirota H, et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 5(4), 311-321 (2003)
Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases
Shang X, et al.
Neoplasia, 14(10), 974-IN22-974-IN22 (2012)
Claudin proteins in human cancer: promising new targets for diagnosis and therapy
Morin P J
Cancer Research, 65(21), 9603-9606 (2005)
Claudin-3 expression increases the malignant potential of lung adenocarcinoma cells: role of epidermal growth factor receptor activation
Zhang L, et al.
Testing, 8(14), 23033-23033 (2017)
Probiotics Prevents Sensitization to Oral Antigen and Subsequent Increases in Intestinal Tight Junction Permeability in Juvenile-Young Adult Rats
Tulyeu J, et al.
Microorganisms, 7(10), 463-463 (2019)
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