生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
表单
buffered aqueous solution
种属反应性
human, rat
浓度
~1 mg/mL
技术
immunoblotting: 1-2 μg/mL using A549 cells extracts
immunohistochemistry: 5-10 μg/mL using formalin-fixed, paraffin-embedded rat intestine/duodenum sections
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CLDN3(1365)
rat ... Cldn3(65130)
一般描述
Claudin-3 (CLDN3) is located on the human chromosome at 7q11.23.
免疫原
a synthetic peptide corresponding to an internal sequence of rat Caludin-3, conjugated to KLH
应用
Anti-Claudin-3 antibody produced in rabbit may be used in:
- immunoblotting
- immunohistochemistry
- immunofluorescence
生化/生理作用
Anti-Claudin-3 recognizes human and rat Claudin-3.
Claudin-3 (CLDN3) promotes interactions with other cells in vivo that prevent growth and metastatic potential by assisting the expression of E-cadherin and limiting β-catenin signaling. CLDN3 represents a promising target for cancer detection, diagnosis and therapy. Overexpression of CLDN3 is associated with several neoplasias, such as ovarian, breast, prostate and pancreatic cancers. CLDN3 levels are increased in lung adenocarcinoma cells.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
制备说明
For continuous use, store at 2–8 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Tight junction proteins claudin-3 and claudin-4 control tumor growth and metastases
Shang X, et al.
Neoplasia, 14(10), 974-IN22-974-IN22 (2012)
Williams syndrome deficits in visual spatial processing linked to GTF2IRD1 and GTF2I on chromosome 7q11. 23
Hirota H, et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 5(4), 311-321 (2003)
Claudin proteins in human cancer: promising new targets for diagnosis and therapy
Morin P J
Cancer Research, 65(21), 9603-9606 (2005)
Claudin-3 expression increases the malignant potential of lung adenocarcinoma cells: role of epidermal growth factor receptor activation
Zhang L, et al.
Testing, 8(14), 23033-23033 (2017)
Janyerkye Tulyeu et al.
Microorganisms, 7(10) (2019-10-19)
Increased intestinal permeability is thought to underlie the pathogenesis of food allergy. We explore the mechanism responsible for changes in the morphology and function of the intestinal barrier using a rat model of food allergy, focusing on the contribution of
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