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Merck
CN

SAB4200610

Monoclonal Anti-EXOSC5 antibody produced in mouse

~1.0 mg/mL, clone EXOSC5(A)-2, purified immunoglobulin

别名:

Anti-RRP41B, Anti-RRP46, Anti-Rrp46p, Anti-chronic myelogenous leukemia tumor antigen 28, Anti-exosome complex component RRP46, Anti-exosome complex exonuclease RRP46, Anti-exosome component 5, Anti-exosome component Rrp46, Anti-hRrp46p, Anti-p12B, Anti-ribosomal RNA-processing protein 46

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关于此项目

UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
EXOSC5(A)-2, monoclonal
Application:
IF
Citations:
2

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biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

EXOSC5(A)-2, monoclonal

form

buffered aqueous solution

mol wt

antigen ~25 kDa

species reactivity

human

concentration

~1.0 mg/mL

technique(s)

immunoblotting: 2-5 μg/mL using whole extracts of human HEK-293T cells, immunofluorescence: 2-5 μg/mL using human HeLa cells.

isotype

IgG1

UniProt accession no.

Q9NQT4

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... EXOSC5(56915)

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General description

Monoclonal Anti-EXOSC5 (mouse IgG1 isotype) is derived from the hybridoma EXOSC5(A)-2 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. Exosome component 5 (EXOSC5) also known as exosome complex component RRP46, is a part of the eukaryotic RNA exosome which is non-catalytic. It is located on the human chromosome at 19q13.2.

Immunogen

synthetic peptide corresponding to the N-terminal region of human EXOSC5, conjugated to KLH. The isotype is determined by ELISA using Mouse Monoclonal Antibody Isotyping Reagents (Sigma ISO-2).

Application

Monoclonal Anti-EXOSC5 antibody has been used in
  • immunoblotting
  • immunoprecipitation
  • immunofluorescence

Biochem/physiol Actions

Exosome component 5 (EXOSC5) plays a role in RNA processing anddegrading a target RNA. It has a 3′-5′exoribonuclease activity. It is over expressed in various forms of cancer including lung, prostrate, melanoma and colorectal cancer.

Physical form

solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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存储类别

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
083M4813V

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EXOSC5 as a novel prognostic marker promotes proliferation of colorectal cancer via activating the ERK and AKT pathways
Pan H, et al.
Frontiers in Oncology, 9, 643-643 (2019)
Jillian de Wilde et al.
International journal of cancer, 122(4), 877-888 (2007-10-26)
Although high-risk human papillomavirus (HPV) infection plays a major role in the development of cervical cancer, additive oncogenic events are involved as well. One key event involves increased activity of telomerase resulting from a deregulated expression of its catalytic subunit

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