Monoclonal Anti-Biglycan antibody from mouse

Biglycan (BGN) is class I small leucine rich proteoglycans (SLRP), encoded by the gene mapped to human chromosome Xq28. The encoded protein is characterized with two chondroitin sulfate glycosaminoglycan (GAG) chains attached near its NH₂ terminus. Biglycan is expressed as a constituent of extracellular matrices in various tissues.

Monoclonal Anti-Biglycan (mouse IgG1 isotype) is derived from the hybridoma 905A7 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice.

Monoclonal Anti-Biglycan antibody from mouse may be used in:

• immunoblotting
• immunohistochemistry
• enzyme-linked immunosorbent assay (ELISA)

In vitro studies state that biglycan (BGN) plays a vital role in the connective tissue metabolism by interacting with collagen fibrils-4 and transforming growth factor (TGF)-β and might also enhance neuronal survival. It also plays a crucial role in maintaining the structural integrity of the aortic wall. Variation in the gene expression leads to X-linked, severe, syndromic form of thoracic aortic aneurysm and dissection (TAAD), including hypertelorism, pectus deformity, joint hypermobility, contractures, and mild skeletal dysplasia. In addition, mutation in the gene is associated with the development of Happle syndrome.

Biglycan signaling provides an important link between innate and adaptive immunity. This protein also plays a crucial role in the regulation of inflammation, bone growth, and muscle development and regeneration. Biglycan is involved in various human diseases, such as asthma, atherosclerosis, cancer, diabetes, and kidney disease.

Monoclonal Anti-Biglycan recognizes human and bovine biglycan.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

For extended storage, freezeat -20 °Cin working aliquots. Repeated freezing and thawing,or storage in “frost-free” freezers,is not recommended. If slight turbidity occurs upon prolonged storage, clarify thesolution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.