SAB4200629
Anti-CNTNAP2 (C-terminal) antibody produced in rabbit
affinity isolated antibody
别名:
5430425M22Rik, AUTS15, CASPR2, CDFE, CG6827, CNTNAP2, CT21123, Cell recognition molecule Caspr2 (CASPR2), Dmel CG6827, Dnrx, KIAA0868, LOC559157, NRX, NRXN4, Nrx-IV, Nx IV, PTHSL1, contactin associated protein-like 2, l(3)68Ff, l(3)rsg23, mKIAA0868, rsg23
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关于此项目
UNSPSC Code:
12352203
Species reactivity:
rat, mouse
Technique(s):
immunoblotting: 1-2 μg/mL using whole extracts of rat brain, immunoprecipitation (IP): 2.5-5.0 μg using extracts of mouse brain
Application:
IP
Citations:
3
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
form
buffered aqueous solution
species reactivity
rat, mouse
concentration
~1.0 mg/mL
technique(s)
immunoblotting: 1-2 μg/mL using whole extracts of rat brain, immunoprecipitation (IP): 2.5-5.0 μg using extracts of mouse brain
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... CNTNAP2(66797)
rat ... Cntnap2(500105)
General description
Contactin associated protein-like 2 (CNTNAP2) is a member of the contactin-associated protein family. It is co-localized with Shaker-like K+ channels in the juxtaparanodal region in myelinated axons. CNTNAP2 is mapped on the human chromosome at 7q35-q36.1.
Immunogen
synthetic peptide corresponding to the C-terminal region of mouse CNTNAP2
Application
Anti-CNTNAP2 (C-terminal) antibody produced in rabbit may be used in immunoblotting and immunoprecipitation.
Biochem/physiol Actions
Anti-CNTNAP2 (C-terminal) recognizes mouse and rat CNTNAP2.
Contactin associated protein-like 2 (CNTNAP2) mediates interactions between neurons and glia during nervous system development and is also involved in the localization of potassium channels within differentiating axons. Mutations in the CNTNAP2 gene is associated with autism spectrum disorder (ASD). CNTNAP2 gene mutations also lead to cortical dysplasia-focal epilepsy syndrome (CDFE) and Gilles de la Tourette syndrome.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at -20 °C for up to one month. For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Localization of Caspr2 in myelinated nerves depends on axon-glia interactions and the generation of barriers along the axon
Poliak S, et al.
The Journal of Neuroscience, 21(19), 7568-7575 (2001)
Disruption of the CNTNAP2 gene in at (7; 15) translocation family without symptoms of Gilles de la Tourette syndrome
Belloso J M, et al.
European Journal of Human Genetics, 15(6), 711-713 (2007)
S Poliak et al.
Neuron, 24(4), 1037-1047 (2000-01-07)
Rapid conduction in myelinated axons depends on the generation of specialized subcellular domains to which different sets of ion channels are localized. Here, we describe the identification of Caspr2, a mammalian homolog of Drosophila Neurexin IV (Nrx-IV), and show that
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