Monoclonal Anti-CDA antibody produced in mouse

Monoclonal Anti-CDA (mouse IgG2a isotype) is derived from the hybridoma CDA-40 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to an internal sequence of human CDA conjugated to KLH. CDA (Cytidine deaminase) also known as cytidine aminohydrolase or CDD. The enzyme is active only as an intact tetramer, since three different monomers concur to the formation of each of the four active sites.

synthetic peptide corresponding to an internal sequence of human CDA .

Monoclonal Anti-CDA antibody may be used in several immunochemical techniques including:

• immunoblotting (~16 kDa)
• flow cytometry
• immunocytochemistry

Cytidine deaminase (CDA) is an intracellular enzyme of the pyrimidine salvage pathways. It catalyzes that deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. In addition, It also catalyzes the deamination of cytosine nucleoside analogues such as ARA-C (cytosine arabinoside) and 5-AZA-CdR (5-aza-2′-deoxycytidine) used in chemotherapy, leading to the loss of their pharmacological activity. CDA inhibitors such as tetrahydrouridine (THU) are interesting therapeutically for use in combination with chemotherapy drugs in patients with leukemia, to enhance drugs activity.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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