Monoclonal Anti-RNF4 antibody produced in mouse

RNF4 (ring finger protein 4), initially identified as a transcriptional cofactor, is an E3 ubiquitin ligase. As this protein contains both the SUMO-interacting motif (SIM) and RING finger domains, it links sumoylation to ubiquitination.

synthetic peptide corresponding to a sequence at the C terminal region of human RNF4

RNF4 (ring finger protein 4) plays a wide variety of physiological roles, such as targeting of proteins for degradation, including promyelocytic leukemia protein (PML), CENP-I (centromere protein I), hypoxia-inducible factor (HIF), PARP-1 (poly [ADP-ribose] polymerase 1) etc. It also induces the base excision repair machinery, thus controlling DNA methylation. It is involved in DNA demethylation therefore, promoting gene transcription. RNF4 acts upon the oncogenic protein, Tax, of human T-cell leukemia virus type 1 (HTLV-1), and it regulates its nucleo-cytoplasmic localization. Arsenic trioxide (ATO) facilitates the sumoylation of promyelocytic leukemia (PML) bodies, thus, increasing their RNF4-mediated SUMO-dependent ubiquitylation and degradation. RNF4 functions as a co-regulator of androgen receptor-dependent transcription and is expressed in mice testis. Therefore, it might be involved in spermatid maturation.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

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