Anti-CT-Pro ET1 (C-terminal) antibody produced in rabbit

Endothelin 1 (ET1) is an endothelium-derived peptide. It is synthesized as an inactive form of 212 amino acids and later converted to an active 21 amino acid peptide. The gene encoding it is localized on human chromosome 6p24.1.

Endothelin-1 (ET-1), also known as Preproendothelin-1 (PPET1). PPET1 undergoes several proteolytic cleavages to yield ET-1. Endothelin-1 belongs to the Endothelin family of potent vasoconstrictor peptides. It consists of three structurally-related members, distinct in their pharmacological activities and distribution ET-1, ET-2 and ET-3.

a synthetic peptide corresponding to the C-terminal region of CT-Pro ET1, conjugated to KLH.

Anti-CT-Pro ET1 (C-terminal) antibody produced in rabbit may be used in various immunochemical techniques including immunoblotting using the C-terminal region of human recombinant CTPro ET1 peptide (~5 kDa), immunohistochemistry and immunofluorescence.

Endothelin 1 (ET1) is a vasoconstrictor and is involved in pulmonary vascular homeostasis. ET1 has been linked to HIV (human immunodeficiency virus)-associated pulmonary arterial hypertension and endothelial dysfunction.

Endothelin-1 (ET-1) plays an important role in various tissues. It is involved in pathogenesis of cardiovascular diseases. Indeed, circulating ET-1 levels are increased in most cardiovascular diseases. The active ET-1 peptide and C-terminal-pro-ET1 (CT-pro-ET1) peptide plasma levels are elevated in heart failure and after acute myocardial infarction (AMI), and give prognostic information on mortality. CT-proET-1 may represent a clinically useful marker of prognosis after AMI.

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

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