SAB4200677
Monoclonal Anti-HAVCR1 antibody produced in mouse
clone KM-23, purified from hybridoma cell culture
别名:
HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, hepatitis A virus cellular receptor 1
生物来源
mouse
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
KM-23, monoclonal
表单
buffered aqueous solution
分子量
antigen 38 kDa
种属反应性
human, rat
浓度
~1 mg/mL
技术
immunoblotting: 2-4 μg/mL using whole extract of human 769-P cells.
immunofluorescence: 1-2 μg/mL using human 769-P cells.
immunohistochemistry: 10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human kidney sections and Biotin/ExtrAvidin®-Peroxidase staining system.
同位素/亚型
IgG2a
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HAVCR1(26762)
rat ... Havcr1(286934)
一般描述
Monoclonal Anti-HAVCR1 (mouse IgG2a isotype) is derived from the KM-23 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse BALB/c mice. Hepatitis A virus cellular receptor 1 (HAVCR1) belongs to the T-cell immunoglobulin mucin (TIM)-family proteins. Human HAVCR1 is predominantly expressed in epithelial and T helper (TH) cells. It is a transmembrane type I epithelial cell protein. HAVCR1 is composed of immunoglobulin (Ig)-like domain and mucin domains in its ectodomain.
免疫原
a synthetic peptide corresponding to a sequence at the internal region of human HAVCR1
应用
Monoclonal Anti-HAVCR1 antibody produced in mouse may be used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
生化/生理作用
Hepatitis A virus cellular receptor 1 (HAVCR1) enhances infection of several virus types such as filovirus, alphavirus, flavivirus and arenavirus due to its involvement in glycoproteins dependent and independent attachment of viral particles to cell membrane. HAVCR1 also inhibits human immunodeficiency virus-1 (HIV-1) replication in CD4+ T cells and inhibit additional virus release, including murine leukemia virus (MLV) and Ebola virus (EBOV) through its phosphatidylserine (PS) receptor. It is involved in cell proliferation and apoptotic body uptake. HAVCR1 expression is increased in proximal tubule epithelial cells in the kidney during ischemic acute renal failure.
Monoclonal Anti-HAVCR1 recognizes human and rat HAVCR1.
外形
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
制备说明
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
法律信息
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Molecular biomarker candidates of acute kidney injury in zero-hour renal transplant needle biopsies
Korbely R, et al.
Transplant International : Official Journal of the European Society For Organ Transplantation, 24(2), 143-149 (2011)
Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein
Nakajima T, et al.
Genes and Immunity, 6(5), 398-406 (2005)
Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions
Tami C, et al.
Journal of virology, 81(7), 3437-3446 (2007)
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