SAB4200677
Monoclonal Anti-HAVCR1 antibody produced in mouse
clone KM-23, purified from hybridoma cell culture
别名:
HAVCR, HAVCR-1, KIM-1, KIM1, TIM, TIM-1, TIM1, TIMD-1, TIMD1, hepatitis A virus cellular receptor 1
登录 查看组织和合同定价。
选择尺寸
关于此项目
NACRES:
NA.41
UNSPSC Code:
51111800
Conjugate:
unconjugated
Clone:
KM-23, monoclonal
Application:
IF, IHC
Citations:
3
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
KM-23, monoclonal
form
buffered aqueous solution
mol wt
antigen 38 kDa
species reactivity
human, rat
concentration
~1 mg/mL
technique(s)
immunoblotting: 2-4 μg/mL using whole extract of human 769-P cells., immunofluorescence: 1-2 μg/mL using human 769-P cells., immunohistochemistry: 10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human kidney sections and Biotin/ExtrAvidin®-Peroxidase staining system.
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
Gene Information
human ... HAVCR1(26762)
rat ... Havcr1(286934)
target post-translational modification
unmodified
General description
Monoclonal Anti-HAVCR1 (mouse IgG2a isotype) is derived from the KM-23 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse BALB/c mice. Hepatitis A virus cellular receptor 1 (HAVCR1) belongs to the T-cell immunoglobulin mucin (TIM)-family proteins. Human HAVCR1 is predominantly expressed in epithelial and T helper (TH) cells. It is a transmembrane type I epithelial cell protein. HAVCR1 is composed of immunoglobulin (Ig)-like domain and mucin domains in its ectodomain.
Immunogen
a synthetic peptide corresponding to a sequence at the internal region of human HAVCR1
Application
Monoclonal Anti-HAVCR1 antibody produced in mouse may be used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
Hepatitis A virus cellular receptor 1 (HAVCR1) enhances infection of several virus types such as filovirus, alphavirus, flavivirus and arenavirus due to its involvement in glycoproteins dependent and independent attachment of viral particles to cell membrane. HAVCR1 also inhibits human immunodeficiency virus-1 (HIV-1) replication in CD4+ T cells and inhibit additional virus release, including murine leukemia virus (MLV) and Ebola virus (EBOV) through its phosphatidylserine (PS) receptor. It is involved in cell proliferation and apoptotic body uptake. HAVCR1 expression is increased in proximal tubule epithelial cells in the kidney during ischemic acute renal failure.
Monoclonal Anti-HAVCR1 recognizes human and rat HAVCR1.
Physical form
Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide.
Preparation Note
For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.
Legal Information
ExtrAvidin is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Evidence for natural selection in the HAVCR1 gene: high degree of amino-acid variability in the mucin domain of human HAVCR1 protein
Nakajima T, et al.
Genes and Immunity, 6(5), 398-406 (2005)
Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions
Tami C, et al.
Journal of virology, 81(7), 3437-3446 (2007)
Molecular biomarker candidates of acute kidney injury in zero-hour renal transplant needle biopsies
Korbely R, et al.
Transplant International : Official Journal of the European Society For Organ Transplantation, 24(2), 143-149 (2011)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持