Anti-MAPK3 antibody, Mouse monoclonal

Anti-MAPK3 antibody, Mouse monoclonal (mouse IgG2a isotype) is derived from the mapk3-4 hybridoma, produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mouse. Mitogen-activated protein kinase 3 (MAPK3) is a serine/threonine protein kinase. It is an essential component of the MAP kinase signal transduction pathway.

synthetic peptide from the N-terminal region of human MAPK3, conjugated to KLH.

Anti-MAPK3 antibody, Mouse monoclonal may be used in immunoblotting and immunoprecipitation.

Mitogen-activated protein (MAP) kinase signal transduction pathway participates in the regulation of a large variety of processes, including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation and transcription. Mitogen-activated protein kinase 3 (MAPK3) is phosphorylated on Thr-202 and Tyr-204 due to activation by upstream kinases, such as MAP2K1/MEK1 and MAP2K2/MEK2, which results in translocation into the nucleus where it, in turn, phosphorylates nuclear targets. MAPK3 is known as an important target in the diagnosis and treatment of several diseases including cancer, cardiac hypertrophy and influenza A infection.

Monoclonal Anti-MAPK3 specifically recognizes human and monkey MAPK3. Monoclonal Anti-MAPK3 does not show cross reactivity with MAPK1 (ERK2)

Solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

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