SAB4200737
Anti-MART-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-MART-1, Anti-MART1, Anti-MLANA, Anti-Melanoma antigen recognized by T-cells 1
生物来源
rabbit
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~13 kDa
种属反应性
human
浓度
~1.0 mg/mL
技术
immunoblotting: 2-4 μg/mL using human melanoma SK-Mel-28 cell line extract
immunofluorescence: 0.25-0.5 μg/mL using human melanoma SK-Mel-28 cell line
immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human melanoma sections
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MART-1(2315)
一般描述
Anti-MART-1 is produced in rabbit using a synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to keyhole limpet hemocyanin (KLH). Melanoma antigen recognized by T-cells 1 (MART-1), also known as melan-A antigen, LB39-AA or antigen SK29-AA, is a type III signal-anchor protein that is localized mainly to the endoplasmic reticulum, the trans-Golgi network and melanosomes. MART-1 protein is expressed specifically in normal skin, retina, melanocyte cell lines and melanomas. It is a melanoma antigen recognized by T-cells and belongs to the melanocyte differentiation markers.
免疫原
synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to KLH
应用
Anti-MART-1 antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
生化/生理作用
Melanoma antigen recognized by T-cells 1 (MART-1) is specifically recognized by human leukocyte antigen (HLA-A2) restricted tumor-infiltrating T lymphocytes (TIL-1) in melanoma patients and is suggested to be involved in tumor progression. It is also involved in pigmentation process and is suggested as a candidate marker for albinism.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Serological analysis of Melan-A (MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas
Chen YT, et al.
Proceedings of the National Academy of Sciences of the USA, 93(12), 5915-5919 (1996)
The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins
De MAM, et al.
Traffic, 3(9), 678-693 (2002)
Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas
Takeuchi H, et al.
Cancer Research, 63(2), 441-448 (2003)
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