SAB4200737
Anti-MART-1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-MART-1, Anti-MART1, Anti-MLANA, Anti-Melanoma antigen recognized by T-cells 1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352202
Clone:
polyclonal
Species reactivity:
human
Application:
IF, IHC
Citations:
3
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~13 kDa
species reactivity
human
concentration
~1.0 mg/mL
technique(s)
immunoblotting: 2-4 μg/mL using human melanoma SK-Mel-28 cell line extract, immunofluorescence: 0.25-0.5 μg/mL using human melanoma SK-Mel-28 cell line, immunohistochemistry: 5-10 μg/mL using heat-retrieved formalin-fixed, paraffin-embedded human melanoma sections
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MART-1(2315)
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General description
Anti-MART-1 is produced in rabbit using a synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to keyhole limpet hemocyanin (KLH). Melanoma antigen recognized by T-cells 1 (MART-1), also known as melan-A antigen, LB39-AA or antigen SK29-AA, is a type III signal-anchor protein that is localized mainly to the endoplasmic reticulum, the trans-Golgi network and melanosomes. MART-1 protein is expressed specifically in normal skin, retina, melanocyte cell lines and melanomas. It is a melanoma antigen recognized by T-cells and belongs to the melanocyte differentiation markers.
Immunogen
synthetic peptide corresponding to a sequence from the internal region of human MART-1 protein, conjugated to KLH
Application
Anti-MART-1 antibody produced in rabbit has been used in:
- immunoblotting
- immunofluorescence
- immunohistochemistry
Biochem/physiol Actions
Melanoma antigen recognized by T-cells 1 (MART-1) is specifically recognized by human leukocyte antigen (HLA-A2) restricted tumor-infiltrating T lymphocytes (TIL-1) in melanoma patients and is suggested to be involved in tumor progression. It is also involved in pigmentation process and is suggested as a candidate marker for albinism.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas
Takeuchi H, et al.
Cancer Research, 63(2), 441-448 (2003)
Serological analysis of Melan-A (MART-1), a melanocyte-specific protein homogeneously expressed in human melanomas
Chen YT, et al.
Proceedings of the National Academy of Sciences of the USA, 93(12), 5915-5919 (1996)
The melanocytic protein Melan-A/MART-1 has a subcellular localization distinct from typical melanosomal proteins
De MAM, et al.
Traffic, 3(9), 678-693 (2002)
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