SAB4200809
Anti-Epidermal Growth Factor (EGF) Receptor, Mouse monoclonal
clone 29.1, purified from hybridoma cell culture
别名:
EGFR, Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1
产品名称
Anti-Epidermal Growth Factor (EGF) Receptor, Mouse monoclonal, clone 29.1, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
29.1, monoclonal
form
buffered aqueous solution
mol wt
~170 kDa
species reactivity
human, bovine, mouse
packaging
antibody small pack of 25 μL
concentration
~1 mg/mL
technique(s)
immunoblotting: 0.5-1 μg/mL using human epidermoid carcinoma A431 cell line extract.
immunofluorescence: 2-4 μg/mL using human epidermoid carcinoma A431 cells.
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... EGFR(1956)
Application
Monoclonal Anti-Epidermal Growth Factor (EGF) Receptor specifically bind to a carbohydrate residue on the external region of the EGF receptor molecule with no interference to the binding of EGF to its receptor, nor does it influence the binding of other monoclonal antibodies to the EGF Receptor. Reactivity has been observed with EGF receptors from mouse, human and bovine origin. The antibody is recommended to use in various immunological techniques, including Immunobloting (~170 kDa), Immunoprecipitation, flow cytometry (FACS), Immunohistochemistry and Immunofluorescence.
General description
Epidermal growth factor receptor (EGFR), also known as Proto-oncogene c-ErbB-1, Receptor tyrosine-protein kinase erbB-1 or HER-1, is an integral cell membrane protein which spans the membranes of a wide range of normal and malignant epithelial cells. EGFR is a tyrosine-specific protein kinase domain, it has an extracellular region which binds EGF and an intra-cellular carboxy-terminal region which possesses the tyrosine kinase activity. EGF binding to its specific EGFR, results in an increased DNA synthesis initiating a signaling cascades including cell proliferation, differentiation and repair of damaged epithelial tissue.
Immunogen
Paraformaldehyde-fixed carcinoma cell line A431
Other Notes
This product is for R&D use only, not for drug, household, or other uses.
Physical form
Supplied as a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide as a preservative.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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