Anti-phospho-TP53 (pSer¹⁵) antibody produced in rabbit

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over.

Peptide sequence around phosphorylation site of serine 15 (P-L-S(p)-Q-E), according to the protein TP53.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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