SAB4300159
Anti-phospho-SMC1A (pSer957) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-CDLS2 antibody produced in rabbit, Anti-DKFZp686L19178 antibody produced in rabbit, Anti-DXS423E antibody produced in rabbit, Anti-KIAA0178 antibody produced in rabbit, Anti-structural maintenance of chromosomes 1A antibody produced in rabbit
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所有图片(2)
About This Item
UNSPSC代码:
12352203
NACRES:
NA.41
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~145 kDa
种属反应性
human
浓度
1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(G-S-SP-Q-G)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pSer957)
基因信息
human ... SMC1A(8243)
免疫原
Peptide sequence around phosphorylation site of serine 957 (G-S-S(p)-Q-G), according to the protein SMC1A.
特点和优势
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目标描述
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint.
外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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