Anti-phospho-PTK2B (pTyr⁴⁰²) antibody produced in rabbit

Involved in calcium induced regulation of ion channel and activation of the map kinase signaling pathway. May represent an important signaling intermediate between neuropeptide activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. Interacts with the SH2 domain of Grb2. May phosphorylate the voltage-gated potassium channel protein Kv1.2. Its activation is highly correlated with the stimulation of c-Jun N-terminal kinase activity. Involved in osmotic stress-dependent SNCA 'Tyr-125' phosphorylation.

Protein tyrosine kinase 2β (PTK2B) is a member of the focal adhesion kinase family which is expressed in the brain. The gene encoding it is localized on human chromosome 8.

Peptide sequence around phosphorylation site of tyrosine 402 (D-I-Y(p)-A-E), according to the protein PTK2B.

Protein tyrosine kinase 2 β (PTK2B) takes part in the β₂-mediated signaling pathway and activates mitogen activated protein kinase pathway. The protein has been shown to be upregulated in many tumors. PTK2B also has a role in cell proliferation and migration. It regulates ion channels which are induced by calcium.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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