SAB4300280
Anti-phospho-CDK6 (pTyr24) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-MGC59692 antibody produced in rabbit, Anti-PLSTIRE antibody produced in rabbit, Anti-STQTL11 antibody produced in rabbit, Anti-cyclin-dependent kinase 6 antibody produced in rabbit
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~36 kDa
种属反应性
rat, human, mouse
浓度
1 mg/mL
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(G-A-YP-G-K)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
phosphorylation (pTyr24)
基因信息
human ... CDK6(1021)
一般描述
CDK6 (cyclin dependent kinase 6) is a serine/threonine kinase. It is a human PLSTIRE gene product that is located on chromosome 7q21.
Probably involved in the control of the cell cycle. Interacts with D-type G1 cyclins.
免疫原
Peptide sequence around phosphorylation site of tyrosine 24 (G-A-Y(p)-G-K), according to the protein CDK6.
生化/生理作用
CDK6 (cyclin dependent kinase 6) participates in the regulation of cell‐cycle, hence it acts as a target for cancer therapy. Upregulation of CDK6 has been observed in various malignancies like leukemia and lymphomas. In hematopoietic stem cells, CDK6 modulates the exit of quiescence.
特点和优势
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外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Identification of G1 kinase activity for cdk6, a novel cyclin D partner
Meyerson M and Harlow E
Molecular and Cellular Biology (1994)
In B-cell chronic lymphocytic leukemias, 7q21 translocations lead to overexpression of the CDK6 gene
Hayette S, et al.
Blood (2003)
Palbociclib can overcome mutations in cyclin dependent kinase 6 that break hydrogen bonds between the drug and the protein
Hernandez Maganhi S, et al.
Protein Science (2017)
MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL
van der Linden MH, et al.
Cell Cycle (2014)
CDK6 levels regulate quiescence exit in human hematopoietic stem cells
Laurenti E, et al.
Cell Stem Cell (2015)
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