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Merck
CN

SAB4300350

Sigma-Aldrich

Anti-ERBB2 (Ab-1221/1222) antibody produced in rabbit

affinity isolated antibody

别名:

Anti-CD340 antibody produced in rabbit, Anti-HER-2 antibody produced in rabbit, Anti-HER-2/neu antibody produced in rabbit, Anti-HER2 antibody produced in rabbit, Anti-v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro / glioblastoma derived oncogene homolog (avian) antibody produced in rabbit

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关于此项目

UNSPSC代码:
12352203
NACRES:
NA.41

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生物来源

rabbit

质量水平

100

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

分子量

~185 kDa

种属反应性

human

浓度

1 mg/mL

技术

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100
indirect immunofluorescence: 1:100-1:200
western blot: 1:500-1:1000

同位素/亚型

IgG

免疫原序列

(N-L-Y-Y-W)

NCBI登记号

NP_001005862.1

UniProt登记号

P04626

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... ERBB2(2064)

相关类别

一般描述

ERBB2 (erb-b2 receptor tyrosine kinase 2) is a tyrosine kinase receptor that belongs to the ErbB family. It is also known as HER2/Neu. It is located on chromosome 17q12.
Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin.

免疫原

Peptide sequence around aa. 1219-1223/1220-1224 (N-L-Y-Y -W), according to the protein ERBB2.

生化/生理作用

ERBB2 (erb-b2 receptor tyrosine kinase 2) is considered as a therapeutic target in breast cancer. It controls the concentration of intracellular calcium in SKBR3 (breast cancer cell line) cells.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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储存分类代码

10 - Combustible liquids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
511721071

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HER2 signaling regulates HER2 localization and membrane retention
Jeong J, et al.
PLoS ONE (2017)
Detection and mapping of amplified DNA sequences in breast cancer by comparative genomic hybridization
Kallioniemi A, et al.
Proceedings of the National Academy of Sciences of the USA (1994)
The HER2 phenotype of circulating tumor cells in HER2-positive early breast cancer: A translational research project of a prospective randomized phase III trial
Jaeger BAS, et al.
PLoS ONE (2017)

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