SAB4300435
Anti-NOS3 (Ab-1177) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-ECNOS antibody produced in rabbit, Anti-eNOS antibody produced in rabbit, Anti-nitric oxide synthase 3 (endothelial cell) antibody produced in rabbit
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~140 kDa
species reactivity
human, mouse, rat
concentration
1 mg/mL
technique(s)
indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(T-Q-S-F-S)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... NOS3(4846)
General description
NOS3 (nitric oxide synthase 3) is located on human chromosome 7q36.
Produces nitric oxide (NO) which is implicated in vascular smooth muscle relaxation through a cGMP-mediated signal transduction pathway. NO mediates vascular endothelial growth factor (VEGF)-induced angiogenesis in coronary vessels and promotes blood clotting through the activation of platelets.
Immunogen
Peptide sequence around aa. 1175-1179 (T-Q-S-F-S), according to the protein NOS3.
Application
Anti-NOS3 (Ab-1177) antibody has been used in western blotting.
Biochem/physiol Actions
Modifications in the NOS3 (nitric oxide synthase 3) gene leads to erectile dysfunction susceptibility, age of onset and severity. In heart, NOS3 helps in NO (nitric oxide) synthesis. It also controls vascular tone and blood pressure.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Gestational diabetes and the adenosine/L-arginine/nitric oxide (ALANO) pathway in human umbilical vein endothelium
San Martin R and Sobrevia L
Placenta, 27(1), 1-10 (2006)
Functional Variations in the NOS3 Gene Are Associated With Erectile Dysfunction Susceptibility, Age of Onset and Severity in a Han Chinese Population
Yang B, et al.
Journal of Sexual Medicine, 14(4), 551-557 (2017)
Endothelial nitric oxide synthase gene single nucleotide polymorphisms and the risk of hypertension: A meta-analysis involving 63,258 subjects
Xie X, et al.
Clinical and Experimental Hypertension, 39(2), 175-182 (2017)
Pressure overload-induced LV hypertrophy and dysfunction in mice are exacerbated by congenital NOS3 deficiency
Ichinose F, et al.
American Journal of Physiology. Heart and Circulatory Physiology, 286(3), H1070-H1075 (2004)
Gang Ren et al.
Scientific reports, 9(1), 6688-6688 (2019-05-02)
One third of newly diagnosed breast cancers in the US are early-stage lesions. The etiological understanding and treatment of these lesions have become major clinical challenges. Because breast cancer risk factors are often linked to aberrant nitric oxide (NO) production
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