Anti-PXN (Ab-88) antibody produced in rabbit

Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion).

PXN (paxillin) is a focal adhesion-associated tyrosine-based protein, that is present in the cytoplasm. It is a 68kDa protein that is located on chromosome 12q24.

Peptide sequence around aa. 86-90 (P-V-Y-G-S), according to the protein PXN.

Anti-PXN (Ab-88) antibody has been used in immunofluorescence.

Paxillin (PXN) controls signal transduction, cell morphology and motility, cytoskeletal rearrangements, proliferation and apoptosis. It serves as an oncogene, hence it plays a major role in the growth of human carcinomas.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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