生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
~74 kDa
种属反应性
rat, mouse, human
浓度
1 mg/mL
技术
western blot: 1:500-1:1000
同位素/亚型
IgG
免疫原序列
(I-R-R-Q-R)
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MELK(9833)
一般描述
Maternal embryonic leucine zipper kinase (MELK) is a serine/threonine kinase that exists in bi-lobal conformation. Structurally, MELK comprises an N-terminal catalytic domain, ubiquitin-associated (UBA) domain, and a kinase domain. The MELK gene is mapped to human chromosome location 9p13.2.The MELK antibody detects endogenous levels of total MELK protein.
Phosphorylates ZNF622 and may contribute to its redirection to the nucleus. May be involved in the inhibition of spliceosome assembly during mitosis.
免疫原
Peptide sequence around aa. 626-630 (I-R-R-Q-R), according to the protein NP_055606.1
应用
Anti-MELK antibody produced in rabbit has been used in western blotting at a dilution of 1:1000.
生化/生理作用
Maternal embryonic leucine zipper kinase (MELK) participates in cell cycle regulation by interacting with cell cycle proteins. It may have a role in malignant cell survival and cancer stem cell growth. An elevated expression of MELK is observed in triple-negative breast cancer, glioblastoma multiforme(GBM), and astrocytomas.
特点和优势
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外形
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
此项目有
Krzysztof P Rembacz et al.
Archives of biochemistry and biophysics, 671, 1-7 (2019-05-21)
Maternal Embryonic Leucine Zipper Kinase (MELK) is overexpressed in various tumors which has been convincingly linked to tumor cell survival. As such, MELK became an interesting target for pharmacological intervention. In this study we present the crystal structure of MELK
Marisa Simon et al.
PloS one, 12(2), e0172832-e0172832 (2017-02-25)
Triple-negative breast cancer (TNBC) is an aggressive, highly recurrent breast cancer subtype, affecting approximately one-fifth of all breast cancer patients. Subpopulations of treatment-resistant cancer stem cells within the tumors are considered to contribute to disease recurrence. A potential druggable target
Arnold Bolomsky et al.
Haematologica, 103(2), 325-335 (2017-11-11)
Treatment of high-risk patients is a major challenge in multiple myeloma. This is especially true for patients assigned to the gene expression profiling-defined proliferation subgroup. Although recent efforts have identified some key players of proliferative myeloma, genetic interactions and players
Suely K N Marie et al.
International journal of cancer, 122(4), 807-815 (2007-10-26)
We have performed cDNA microarray analyses to identify gene expression differences between highly invasive glioblastoma multiforme (GBM) and typically benign pilocytic astrocytomas (PA). Despite the significant clinical and pathological differences between the 2 tumor types, only 63 genes were found
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