产品名称
Anti-Histone H4R3me2s antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
11 kDa
species reactivity
rat, mouse, human
concentration
1.0 mg/mL
technique(s)
immunohistochemistry: 1:50- 1:200
western blot: 1:500-1:2000 (Cell Lysate)
isotype
IgG
accession no.
NP_003539.1
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
dimethylation (Arg3)
Quality Level
Gene Information
human ... HIST2H4A(8370)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Immunogen
A synthetic peptide corresponding to the amino terminus of histone H4 in which Arg3 is di-methylated.
Physical form
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
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存储类别
10 - Combustible liquids
wgk
WGK 1
法规信息
常规特殊物品
此项目有
Satya K Kota et al.
Bone, 117, 37-46 (2018-09-07)
Protein arginine methyltransferases (PRMTs) catalyze symmetric and asymmetric methylation on arginine residues of multiple protein targets including histones and have essential roles in organismal development and disease. PRMT5 mediates symmetric di-methylation (sDMA) of arginine 2 (H3R2me2s) and arginine 8 on
Zhiwei Zheng et al.
Journal of pharmaceutical analysis, 13(6), 590-602 (2023-07-13)
This study aimed to evaluate the therapeutic potential of inhibiting protein arginine methyltransferase 5 (PRMT5) in cisplatin-induced hearing loss. The effects of PRMT5 inhibition on cisplatin-induced auditory injury were determined using immunohistochemistry, apoptosis assays, and auditory brainstem response. The mechanism
Stephanie A Amici et al.
Frontiers in immunology, 12, 695947-695947 (2021-06-26)
Multiple Sclerosis (MS) is a debilitating central nervous system disorder associated with inflammatory T cells. Activation and expansion of inflammatory T cells is thought to be behind MS relapses and influence disease severity. Protein arginine N-methyltransferase 5 (PRMT5) is a
PRMT5 in T Cells Drives Th17 Responses, Mixed Granulocytic Inflammation, and Severe Allergic Airway Inflammation.
Lewis, et al.
Journal of immunology (Baltimore, Md. : 1950), 208, 1525-1533 (2023)
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