biological source
rabbit
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
62 kDa
species reactivity
human, mouse, rat
concentration
0.5 mg/mL
technique(s)
immunohistochemistry: 1:10- 1:50, western blot: 1:200-1:1000 (Cell Lysate)
isotype
IgG
accession no.
NP_001240652.1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DPYSL5(56896)
General description
Dihydropyrimidinase like 5 (DPYSL5) or collapsin response mediator protein 5 (CRMP5) is a cytosolic protein. It is expressed in regions of neurogenesis in the brain. CRMP5 is part of the CRMP cytosolic phosphoprotein family and the gene encoding it is localized on human chromosome 2p23.3.
Immunogen
Synthetic peptide corresponding to a region derived from 504-518 amino acids of Human Collapsin response mediator protein 5
Biochem/physiol Actions
Collapsin response mediator protein 5 (CRMP5) or dihydropyrimidinase like 5 (DPYSL5) has a role in the development and repair of the nervous system. It has been associated with paraneoplastic neurologic syndromes and is a biomarker for high-grade lung neuroendocrine carcinomas.
The antibody detects endogenous level of total CRMP5 protein.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Supplied at 0.5mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Insights into the oligomerization of CRMPs: crystal structure of human collapsin response mediator protein 5.
Ponnusamy R and Lohkamp B
Journal of Neurochemistry, 125(6), 855-868 (2013)
CRMP5 controls glioblastoma cell proliferation and survival through notch-dependent signaling.
Moutal A, et al.
Cancer Research, 75(17), 3519-3528 (2015)
Transethnic insight into the genetics of glycaemic traits: fine-mapping results from the Population Architecture using Genomics and Epidemiology (PAGE) consortium.
Bien S A, et al.
Diabetologia, 60(12), 2384-2398 (2017)
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