SAB4500088
Anti-β-Tubulin III Antibody
rabbit polyclonal
别名:
TUBB3, TUBB4, 微管蛋白 β-3链, 微管蛋白 β-III, 微管蛋白β-4
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Species reactivity:
human, mouse, rat
Citations:
15
Technique(s):
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
Uniprot accession no.:
产品名称
抗-微管蛋白 β 兔抗, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 50 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TUBB3(10381)
Physical form
兔IgG，溶于磷酸盐缓冲液（不含Mg2+和Ca2+），pH 7.4,150mM NaCl，0.02％叠氮化钠和50％甘油中。
Biochem/physiol Actions
微管蛋白β-III（TUBB3）的上调在膀胱癌中显示出强烈的肿瘤特征和遗传不稳定性。它参与染色体的分离。先天性眼外肌3型纤维化（CFEOM3）的个体在TUBB3中显示突变。βIII-微管蛋白调节葡萄糖代谢，从而改变葡萄糖饥饿应激信号传导，从而在非小细胞肺癌细胞中发展细胞增殖和存活。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
General description
微管蛋白β-III（TUBB3）是微管的组成部分。它在成熟的神经元中表达。它位于人染色体16q24上。
抗微管蛋白β 抗体可检测总微管β 蛋白的内源水平。
抗微管蛋白β 抗体可检测总微管β 蛋白的内源水平。
Immunogen
该抗血清是针对衍生自人微管蛋白β的合成肽而生成的。
免疫原范围： 401-450
免疫原范围： 401-450
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
?III-Tubulin alters glucose metabolism and stress response signaling to promote cell survival and proliferation in glucose-starved non-small cell lung cancer cells
Parker AL, et al.
Carcinogenesis (2016)
Chuchu Gong et al.
Journal of cellular and molecular medicine, 27(15), 2165-2182 (2023-06-30)
Sulfur mustard (SM) is a blister-producing chemical warfare agent which could lead to a cascade of systemic damage, especially severe acute lung injury. Oxidative stress is considered to be vital processes for the SM toxicity mechanism. We previously proved the
?III-tubulin overexpression is linked to aggressive tumor features and genetic instability in urinary bladder cancer
Hinsch A, et al.
Human Pathology (2017)
Yi-Qing Gong et al.
Oncotarget, 7(37), 60123-60132 (2016-08-16)
Excessive Ultra-violet (UV) radiation causes oxidative damages and apoptosis in retinal pigment epithelium (RPE) cells. Here we tested the potential activity of SC79, a novel small molecule activator of Akt, against the process. We showed that SC79 activated Akt in
Mutations in Human Tubulin Proximal to the Kinesin-Binding Site Alter Dynamic Instability at Microtubule Plus- and Minus-Ends
Ti SC, et al.
Developmental Cell (2016)
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