生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 108 kDa
种属反应性
human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... COL6A1(1291)
一般描述
Anti-Collagen VI α1 Antibody detects endogenous levels of total Collagen VI α1 protein.
Collagen type VI α1 chain (COL6A1) is encoded by the gene mapped to long arm of human chromosome 21q22.3. Collagen VI is widely expressed in connective tissue.
免疫原
The antiserum was produced against synthesized peptide derived from human Collagen VI alpha1.
Immunogen Range: 191-240
Immunogen Range: 191-240
应用
Anti-Collagen VI α1 antibody produced in rabbit has been used in immunohistochemistry and cytofluorimetric analysis.
生化/生理作用
Collagen type VI α1 chain (COL6A1) plays a vital role in tumor metastasis. Mutations in the gene leads to Bethlem myopathy. Increased expression of the gene can be considered as an important marker for poor prognosis of clear cell renal cell carcinoma patients.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Novel mutations in collagen VI genes Expansion of the Bethlem myopathy phenotype.
Scacheri PC, et al.
Neurology, 58(4), 593-602 (2002)
Upregulation of COL6A1 is predictive of poor prognosis in clear cell renal cell carcinoma patients
Wan F, et al.
Oncotarget, 6(29), 27378-27378 (2015)
Down syndrome--a gene dosage disease caused by trisomy of genes within a small segment of the long arm of chromosome 21, exemplified by the study of effects from the superoxide-dismutase type 1 (SOD-1) gene.
Anneren G, et al.
APMIS. Supplementum, 40, 71-79 (1993)
Viktorija Aleksiuk et al.
Biomedicines, 11(9) (2023-09-28)
Osteoarthritis (OA) ranks as the prevailing type of arthritis on a global scale, for which no effective treatments are currently available. Arterial hypertension is a common comorbidity in OA patients, and antihypertensive drugs, such as nifedipine (NIF), may affect the
William W MacDonald et al.
Investigative ophthalmology & visual science, 63(6), 8-8 (2022-06-08)
Secreted protein, acidic and rich in cysteine (SPARC) elevates intraocular pressure (IOP), increases certain structural extracellular matrix (ECM) proteins in the juxtacanalicular trabecular meshwork (JCT), and decreases matrix metalloproteinase (MMP) protein levels in trabecular meshwork (TM) endothelial cells. We investigated
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