生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 50 kDa
种属反应性
mouse, human, rat
浓度
~1 mg/mL
技术
ELISA: 1:5000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CSK(1445)
一般描述
The C-terminal Src kinase (CSK) gene is mapped to human chromosome 15q24.1. Anti-CSK Antibody detects endogenous levels of total CSK protein.
免疫原
The antiserum was produced against synthesized peptide derived from human CSK.
Immunogen Range: 31-80
Immunogen Range: 31-80
生化/生理作用
C-terminal Src kinase (CSK) is known to support dengue virus replication. CSK negatively controls Src, an oncogenic protein found to be upregulated in various types of cancer. CSK is responsible for Src phosphorylation at tyrosine 530, which inhibits its activity. It controls immune response, by preventing T cell activation through its association with lymphoid-specific phosphatase. CSK possesses SH2 domain, a regulatory domain that mediates its binding to scaffold proteins for membrane translocation. This regulation is known to elevate CSK′s activity.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Genome-wide association analyses on blood pressure using three different phenotype definitions
JW Park, et al.
Genomics & informatics, 8(3), 108-115 (2010)
Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schonlein purpura (IgA vasculitis)
Lopez MR, et al.
Scientific reports, 17(1), 286-286 (2015)
Regulation of the SRC family kinases by Csk
Okada Masato
International Journal of Biological Sciences, 8(10), 1385-1385 (2012)
Rinki Kumar et al.
Scientific reports, 6, 30490-30490 (2016-07-28)
We screened a siRNA library targeting human tyrosine kinases in Huh-7 cells and identified c-terminal Src kinase (Csk) as one of the kinases involved in dengue virus replication. Knock-down of Csk expression by siRNAs or inhibition of Csk by an
Bo Kyung Jeon et al.
Scientific reports, 5, 12725-12725 (2015-08-04)
Mitogen-activated protein kinases (MAPKs) are key signal transducers involved in various cellular events such as growth, proliferation, and differentiation. Previous studies have reported that H2O2 leads to phosphorylation of extracellular signal-regulated kinase (ERK), one of the MAPKs in endothelial cells.
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持