SAB4500507
Anti-CSK antibody produced in rabbit
affinity isolated antibody
别名:
C-SRC kinase, Protein-tyrosine kinase CYL
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 50 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CSK(1445)
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General description
The C-terminal Src kinase (CSK) gene is mapped to human chromosome 15q24.1. Anti-CSK Antibody detects endogenous levels of total CSK protein.
Immunogen
The antiserum was produced against synthesized peptide derived from human CSK.
Immunogen Range: 31-80
Immunogen Range: 31-80
Biochem/physiol Actions
C-terminal Src kinase (CSK) is known to support dengue virus replication. CSK negatively controls Src, an oncogenic protein found to be upregulated in various types of cancer. CSK is responsible for Src phosphorylation at tyrosine 530, which inhibits its activity. It controls immune response, by preventing T cell activation through its association with lymphoid-specific phosphatase. CSK possesses SH2 domain, a regulatory domain that mediates its binding to scaffold proteins for membrane translocation. This regulation is known to elevate CSK′s activity.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Genome-wide association analyses on blood pressure using three different phenotype definitions
JW Park, et al.
Genomics & informatics, 8(3), 108-115 (2010)
Role of PTPN22 and CSK gene polymorphisms as predictors of susceptibility and clinical heterogeneity in patients with Henoch-Schonlein purpura (IgA vasculitis)
Lopez MR, et al.
Scientific reports, 17(1), 286-286 (2015)
Regulation of the SRC family kinases by Csk
Okada Masato
International Journal of Biological Sciences, 8(10), 1385-1385 (2012)
Rinki Kumar et al.
Scientific reports, 6, 30490-30490 (2016-07-28)
We screened a siRNA library targeting human tyrosine kinases in Huh-7 cells and identified c-terminal Src kinase (Csk) as one of the kinases involved in dengue virus replication. Knock-down of Csk expression by siRNAs or inhibition of Csk by an
Bo Kyung Jeon et al.
Scientific reports, 5, 12725-12725 (2015-08-04)
Mitogen-activated protein kinases (MAPKs) are key signal transducers involved in various cellular events such as growth, proliferation, and differentiation. Previous studies have reported that H2O2 leads to phosphorylation of extracellular signal-regulated kinase (ERK), one of the MAPKs in endothelial cells.
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