SAB4500688
Anti-EDG1 antibody produced in rabbit
affinity isolated antibody
别名:
EDG1, S1P1, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor Edg-1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, WB
Citations:
2
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 42 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000, immunofluorescence: 1:100-1:500, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... S1PR1(1901)
General description
Anti-EDG1 Antibody detects endogenous levels of total EDG1 protein.
EDG1 (endothelial differentiation gene )/S1P1 (sphingosine-1-phosphate receptor 1) is a transmembrane G protein coupled receptor. It belongs to the endothelial differentiation gene (EDG) family of receptors. It is mapped to human chromosome 1p21.
Immunogen
The antiserum was produced against synthesized peptide derived from human EDG1.
Immunogen Range: 5-54
Immunogen Range: 5-54
Biochem/physiol Actions
EDG1 (endothelial differentiation gene )/S1P1 (sphingosine-1-phosphate receptor 1) serve as an anti-apoptotic/pro-proliferative protein in AML (acute myeloid leukemia) cells. It is involved in angiogenesis and lymphangiogenesis. It also acts as a pro-tumorigenic receptor.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
S1PR1 mediates anti?apoptotic/pro?proliferative processes in human acute myeloid leukemia cells
Xu XQ, et al.
Molecular Medicine Reports, 14(4), 3369-3375 (2016)
Mohamad Adada et al.
The FEBS journal, 280(24), 6354-6366 (2013-07-25)
Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid involved in cell proliferation, angiogenesis, inflammation and malignant transformation among other functions. S1P acts either directly on intracellular targets or activates G protein-coupled receptors, specifically five S1P receptors (S1PRs). The identified S1PRs differ
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