SAB4500688
Anti-EDG1 antibody produced in rabbit
affinity isolated antibody
别名:
EDG1, S1P1, Sphingosine 1-phosphate receptor 1, Sphingosine 1-phosphate receptor Edg-1
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 42 kDa
种属反应性
human
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... S1PR1(1901)
一般描述
Anti-EDG1 Antibody detects endogenous levels of total EDG1 protein.
EDG1 (endothelial differentiation gene )/S1P1 (sphingosine-1-phosphate receptor 1) is a transmembrane G protein coupled receptor. It belongs to the endothelial differentiation gene (EDG) family of receptors. It is mapped to human chromosome 1p21.
免疫原
The antiserum was produced against synthesized peptide derived from human EDG1.
Immunogen Range: 5-54
Immunogen Range: 5-54
生化/生理作用
EDG1 (endothelial differentiation gene )/S1P1 (sphingosine-1-phosphate receptor 1) serve as an anti-apoptotic/pro-proliferative protein in AML (acute myeloid leukemia) cells. It is involved in angiogenesis and lymphangiogenesis. It also acts as a pro-tumorigenic receptor.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
12 - Non Combustible Liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
S1PR1 mediates anti?apoptotic/pro?proliferative processes in human acute myeloid leukemia cells
Xu XQ, et al.
Molecular Medicine Reports, 14(4), 3369-3375 (2016)
Mohamad Adada et al.
The FEBS journal, 280(24), 6354-6366 (2013-07-25)
Sphingosine-1-phosphate (S1P) is a potent bioactive sphingolipid involved in cell proliferation, angiogenesis, inflammation and malignant transformation among other functions. S1P acts either directly on intracellular targets or activates G protein-coupled receptors, specifically five S1P receptors (S1PRs). The identified S1PRs differ
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