SAB4501527
Anti-IGFBP-3 antibody produced in rabbit
affinity isolated antibody
别名:
IBP-3, IBP3, IGF-binding protein 3, IGFBP3, Insulin-like growth factor binding protein 3 precursor
生物来源
rabbit
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen 31 kDa
种属反应性
human, mouse
浓度
~1 mg/mL
技术
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
NCBI登记号
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... IGFBP3(3486)
一般描述
Insulin-like growth factor-binding protein 3 (IGFBP3), a multifunctional protein belongs to the insulin-like growth factor binding proteins (IGFBPs) superfamily. The IGFBP3 gene is located on human chromosome 7p12. Anti-IGFBP-3 antibody detects endogenous levels of total IGFBP-3 protein.
免疫原
The antiserum was produced against synthesized peptide derived from human IGFBP-3.
Immunogen Range: 151-200
Immunogen Range: 151-200
生化/生理作用
Insulin-like growth factor-binding protein 3 (IGFBP3) can stimulate cell growth and apoptosis. It participates in DNA repair. Patients with rheumatoid arthritis show an increased level of IGFBP3 in the serum and synovial fluid. It is involved in the proliferation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs). IGFBP3 can suppress insulin-like growth factor-1 (IGF-1) signaling and modulate lung carcinogenesis and cell proliferation.
特点和优势
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外形
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Roman E Ushakov et al.
Biochemical and biophysical research communications, 531(2), 133-139 (2020-08-13)
Insulin-like growth factor binding protein 3 (IGFBP3) is a multifunctional protein, able either to stimulate the cell growth or to promote apoptosis. In particular, IGFBP3 plays significant role in propagation of stress-induced senescence in human endometrium-derived mesenchymal stem cells (MESCs)
K Eggermann et al.
Annales de genetique, 42(2), 117-121 (1999-08-06)
Maternal uniparental disomy (UPD) of chromosome 7 has recently been reported in about 10% of Silver-Russell (SRS) patients. It can therefore be concluded that at least one gene on chromosome 7 is imprinted and mutations in this gene/these genes might
Chia-Chia Chao et al.
Life sciences, 265, 118758-118758 (2020-11-15)
Insulin-like growth factor (IGF) signaling has been documented in several human malignancies and is thought to contribute to cellular differentiation and migration, as well as malignant progression. A major binding molecule of IGF, IGF-binding protein 3 (IGFBP-3), regulates multiple IGF
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