SAB4501980
Anti-Nuclear Factor 1 antibody produced in rabbit
affinity isolated antibody
别名:
CCAAT-box binding transcription factor, CTF, KIAA1439, NF-I/A, NF1-A
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 55 kDa
species reactivity
rat, human, mouse
concentration
~1 mg/mL
technique(s)
ELISA: 1:20000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NF1(4774)
General description
Nuclear factor I A (NF1) belongs to the nuclear factor I family of transcription factors. It exists as four isoforms. The gene encoding NF1 is localized on human chromosome 1p31-p32.
Immunogen
The antiserum was produced against synthesized peptide derived from human Nuclear Factor 1.
Immunogen Range: 11-60
Immunogen Range: 11-60
Biochem/physiol Actions
Based on the cell type and promoters, nuclear factor I A (NF1) acts either as an activator or repressor. It has an important role in brain development. NF1 acts as a mediator in glial lineage specification and modulates astrocyte terminal differentiation. The protein has been shown to inhibit apoptosis in glioblastoma cells. Mutations in the NF1 gene have been linked to chromosome 1p32-p31 deletion syndrome.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Truncating mutation in NFIA causes brain malformation and urinary tract defects.
Negishi Y, et al.
Human Genome Variation, 2, 15007-15007 (2015)
Loss-of-function variants in NFIA provide further support that NFIA is a critical gene in 1p32-p31 deletion syndrome: A four patient series.
Revah-Politi A, et al.
American Journal of Medical Genetics, 173(12), 3158-3164 (2017)
A novel NFIA-NF?B feed-forward loop contributes to glioblastoma cell survival.
Lee J, et al.
Neuro-Oncology, 19(4), 524-534 (2017)
Linda Marie Starnes et al.
Blood, 114(9), 1753-1763 (2009-06-23)
It is generally conceded that selective combinations of transcription factors determine hematopoietic lineage commitment and differentiation. Here we show that in normal human hematopoiesis the transcription factor nuclear factor I-A (NFI-A) exhibits a marked lineage-specific expression pattern: it is upmodulated
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