Anti-NF-κB p105 antibody produced in rabbit

Anti-NF-κB p105 Antibody detects endogenous levels of total NF-κB p105 protein.

The gene NFκB1(nuclear factor κ B subunit 1) is mapped to human chromosome 4q24. It codes for κB p105/p50 isoforms.

The antiserum was produced against synthesized peptide derived from human NF-kappaB p105/p50.

Immunogen Range: 860-909

NF-κB (nuclear factor κ B) is an important transcription factor that regulates the process of apoptosis, immune response and cell-growth control genes. It is associated with a number of human disorders including inflammatory diseases and cancers. NF-κB signaling cascade is known to be stimulated by many genotoxic stresses and also DNA damage. NF-κB is involved in bone metabolism. Downregulation of NF-κB mediates GPER (G-protein coupled estrogen receptor) specific agonist G-1 induced EMT (epithelial mesenchymal transition) suppression. Thereby, it prevents the motility of triple-negative breast cancer cells in vitro.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.