SAB4502210
Anti-PLD1 antibody produced in rabbit
affinity isolated antibody
别名:
Choline phosphatase 1, Phosphatidylcholine-hydrolyzing phospholipase D1, Phospholipase D1
产品名称
Anti-PLD1 antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 124 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:1000
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PLD1(5337)
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Biochem/physiol Actions
PLD1 (phospholipase D1) is responsible for the hydrolysis of phosphatidylcholine to yield phosphatidic acid and choline. It controls EGFR (epidermal growth factor receptor) endocytosis, which is associated with the process of cell proliferation, differentiation, migration and survival. PLD1 regulates the metabolic flexibility of cancer cells to help it maintain its viability and proliferation in response to stress. Upregulation of the gene is observed in gastric cancer. PLD1 might play an important role in allergic disorders such as asthma.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Anti-PLD1 Antibody detects endogenous levels of total PLD1 protein.
The PLD1 (phospholipase D1) gene is mapped to human chromosome 3q26.31. The protein encoded consists of pleckstrin homology and phox homology domains.
Immunogen
The antiserum was produced against synthesized peptide derived from human PLD1.
Immunogen Range: 527-576
Immunogen Range: 527-576
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
The pleckstrin homology domain of phospholipase D1 accelerates EGFR endocytosis by increasing the expression of the Rab5 effector, rabaptin-5.
Park MH
Experimental & Molecular Medicine, 18;47, 1-8 (2015)
Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells.
Cai M
Cell Death & Disease, 7(11), 1-10 (2016)
MicroRNA-638 inhibits cell proliferation by targeting phospholipase D1 in human gastric carcinoma.
Zhang J
Protein & cell, 6(9), 680-688 (2015)
Comprehensive copy number profiles of breast cancer cell model genomes.
Shadeo A
Breast Cancer Research, 8(1):R9, 1-14 (2006)
The TLR4-associated phospholipase D1 activation is crucial for Der f 2-induced IL-13 production.
Choi HJ
Allergy, 70(12), 1569-1579 (2015)
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