SAB4502602
Anti-CYCLIN D1, C-Terminal antibody produced in rabbit
affinity isolated antibody
别名:
BCL-1 oncogene, BCL1, CYL-1, G1/S-specific cyclin D1, cyclin D1
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IHC, WB
Citations:
8
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 33 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:5000, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CCND1(595)
General description
Anti-CYCLIN D1 antibody detects endogenous levels of total CYCLIN D1 protein.
The CCND1 (cyclin D1) gene is mapped to human chromosome 11q13.3.
Immunogen
The antiserum was produced against synthesized peptide derived from human Cyclin D1.
Immunogen Range: 246-295
Immunogen Range: 246-295
Application
Anti-CYCLIN D1, C-Terminal antibody produced in rabbit has been used in western blotting analysis.
Biochem/physiol Actions
CCND1 (cyclin D1) regulates cell cycle by mediating the G1 to S phase transition. The gene gets activated by β-catenin and participates in the process of tumor formation. Upregulation of the gene is observed in cancer such as lung, breast, colon, hematopoietic and prostate carcinomas, and promotes contact independent cell growth. Variation in CCND1 contributes to increased occurrence of colorectal cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Reduced O-GlcNAcase expression promotes mitotic errors and spindle defects.
Lanza C
Cell Cycle, 15(10), 1363-1375 (2016)
Tumor suppressor role of microRNA-1296 in triple-negative breast cancer.
Phan B
Oncotarget, 7(15), 19519-19530 (2016)
The association between CCND1 G870A polymorphism and colorectal cancer risk: A meta-analysis.
Xie M
Medicine, 96(42), 1-9 (2017)
Array-based comparative genomic hybridization analysis identified cyclin D1 as a target oncogene at 11q13.3 in nasopharyngeal carcinoma.
Hui AB
Cancer Research, 65(18), 8125-8133 (2005)
Chris Lanza et al.
Cell cycle (Georgetown, Tex.), 15(10), 1363-1375 (2016-04-14)
Alterations in O-GlcNAc cycling, the addition and removal of O-GlcNAc, lead to mitotic defects and increased aneuploidy. Herein, we generated stable O-GlcNAcase (OGA, the enzyme that removes O-GlcNAc) knockdown HeLa cell lines and characterized the effect of the reduction in
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