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Merck
CN

SAB4502724

Anti-CIDEC, C-Terminal antibody produced in rabbit

affinity isolated antibody

别名:

Cell death activator CIDE-3, Cell death-inducing DFFA-like effector protein C, FSP27, Fat-specific protein FSP27 homolog

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关于此项目

NACRES:
NA.41
UNSPSC Code:
12352203
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 26 kDa

species reactivity

human

concentration

~1 mg/mL

technique(s)

ELISA: 1:1000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100

NCBI accession no.

UniProt accession no.

shipped in

wet ice

storage temp.

−20°C

Gene Information

human ... CIDEC(63924)

General description

CIDEC (cell death inducing DFFA (DNA fragmentation factor subunit α) like effector c) is mapped to human chromosome 3p25.3. The gene codes for FSP27 (fat-specific protein 27) also known as CIDEC. The encoded protein is localized to the lipid droplets surface. The gene is predominantly expressed in white adipose tissues and also expressed in liver and kidney.
Anti-CIDEC Antibody detects endogenous levels of total CIDEC protein. Cell death-inducing DFFA-like effector protein C (CIDEC) is localized on the surface of lipid droplets in adipocytes.

Immunogen

The antiserum was produced against synthesized peptide derived from human CIDEC.

Immunogen Range: 189-238

Biochem/physiol Actions

CIDEC might be responsible for adipocytes differentiation. It is involved in the regulation of lipid droplet morphology and controls the lipid droplets size by inhibiting lipolysis. It is responsible for the triglycerides buildup in adipocytes. Upregulation of the gene is observed in obesity. Overexpression of the gene decreases the fatty acid oxidation (FAO) rate.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.


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存储类别

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Mandibular hypoplasia, deafness, progeroid features and lipodystrophy (MDPL) syndrome in the context of inherited lipodystrophies.
Reinier F
Metabolism, Clinical and Experimental, 64(11), 1530-1540 (2015)
Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate.
Vila-Brau A
Journal of Lipid Research, 54(3), 592-601 (2013)
Expression of CIDE proteins in clear cell renal cell carcinoma and their prognostic significance.
Yu M
Molecular and Cellular Biochemistry, 378(1-2), 145-151 (2013)