SAB4503757
Anti-phospho-CREB (pSer142) antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 36 kDa
species reactivity
human, mouse, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer142)
Quality Level
Gene Information
human ... CREB1(1385)
General description
CREB1 (cAMP response element-binding protein) gene codes for a 43kDa cellular transcription factor, CREB. It has 341 amino acids. It belongs to the basic leucine zipper family of transcription factors. CREB1 is upregulated abundantly in human tissues and is located on human chromosome 2q33–35.
Immunogen
The antiserum was produced against synthesized peptide derived from human CREB around the phosphorylation site of Ser142.
Immunogen Range: 111-160
Immunogen Range: 111-160
Biochem/physiol Actions
Knockdown of CREB (cAMP response element-binding protein) promotes apoptosis in pre-B acute lymphoblastic leukemia cells by preventing prosurvival signals. It controls the transcription of antiapoptotic proteins in several cell types. Decrease in CREB phosphorylation leads to malfunction of mitochondria and hypoxia-induced apoptosis in chondrocytes.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Effects of the G(-656)A variant on CREB1 promoter activity in a neuronal cell line: interactions with gonadal steroids and stress
Zubenko GS and Hughes HB 3rd
Molecular Psychiatry, 14(4), 390-397 (2009)
Oxidative stress-induced CREB upregulation promotes DNA damage repair prior to neuronal cell death protection
Pregi N, et al.
Molecular and Cellular Biochemistry, 425(1-2), 9-24 (2017)
CREB knockdown inhibits growth and induces apoptosis in human pre-B acute lymphoblastic leukemia cells through inhibition of prosurvival signals
Shabestari RM, et al.
Biomedicine and Pharmacotherapy, 87, 274-279 (2017)
Hypoxia-induced apoptosis and mitochondrial dysfunction in chondrocytes arising from CREB phosphorylation reduction
Qiu YY, et al.
Genetics and molecular research : GMR (2016)
Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo
Francois S, et al.
Journal of Virology, 90(19), 8686-8697 (2016)
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