Anti-phospho-CD19 (pTyr⁵³¹) antibody produced in rabbit

The gene CD19 (B-lymphocyte antigen) is located on human chromosome 16p11. The encoded protein is a transmembrane protein which is specific to B-cells.

The antiserum was produced against synthesized peptide derived from human CD19 around the phosphorylation site of Tyr531.

Immunogen Range: 501-550

CD19 (B-lymphocyte antigen) plays an important role in BCR (B cell receptor) signaling. It serves as a B cell receptor (BCR) co-receptor. In B cells, phosphorylated CD19 induces signaling of SRC-family kinase (SFK) LYN and tyrosine kinases. It also participates in B-cell selection and differentiation. In mice, overexpression of CD19 causes hyper-responsive to BCR induction, thus resulting in lupus-like autoimmune disease. Mutations in this gene can result in common variable immunodeficiency (CVID) in humans.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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