产品名称
Anti-phospho-CD4 (pSer433) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 51 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer433)
Quality Level
Gene Information
human ... CD4(920)
Biochem/physiol Actions
CD4 (CD4 molecule) helps in the activation of immunostimulatory T-cells. It serves as a primary receptor for HIV-1 entry. Individuals with infectious and chronic inflammatory diseases shows higher level of soluble CD4 (sCD4).
Features and Benefits
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General description
CD4 (CD4 molecule) is present in the surface of specific leukocytes. CD4 contains four ecto-domains (D1-D4) of which D1, D2, and D4 contain disulfide bonds. It is mapped to human chromosome 12p13.31. CD4 belongs to the immunoglobulin superfamily (IgSF). It has four extracellular Ig-like domains, a hydrophobic transmembrane region and a 40-residue cytoplasmic tail.
Immunogen
The antiserum was produced against synthesized peptide derived from human CD4 around the phosphorylation site of Ser433.
Immunogen Range: 401-450
Immunogen Range: 401-450
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Increased soluble CD4 in serum of rheumatoid arthritis patients is generated by matrix metalloproteinase (MMP)-like proteinases
Tseng WY, et al.
PLoS ONE (2013)
Federica De Santis et al.
Frontiers in immunology, 13, 830788-830788 (2022-06-07)
A strategy adopted to combat human immunodeficiency virus type-1 (HIV-1) infection is based on interfering with virus entry into target cells. In this study, we found that phosphatidylcholine (PC) liposomes reduced the expression of the CD4 receptor in human primary
Isochromosomes 12p and 9p: parental origin and possible mechanisms of formation
Dutly F, et al.
European Journal of Human Genetics, 6(2), 140-144 (1998)
Human CD4 Metastability Is a Function of the Allosteric Disulfide Bond in Domain 2
Owen GR, et al.
Biochemistry, 55(15), 2227-2237 (2016)
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