SAB4504665
Anti-phospho-BL-CAM (pTyr807) antibody produced in rabbit
affinity isolated antibody
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 95 kDa
species reactivity
mouse, rat, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr807)
Gene Information
human ... CD22(933)
General description
CD22 (cluster of differentiation 22) is a 140 kDa single-spanning membrane glycoprotein present on the surface of B cells. This gene belongs to the sialic acid-binding Ig-type lectin (Siglec) family. CD22 is mapped to human chromosome 19q13.
Immunogen
The antiserum was produced against synthesized peptide derived from human BL-CAM around the phosphorylation site of Tyr807.
Immunogen Range: 776-825
Immunogen Range: 776-825
Biochem/physiol Actions
CD22 (cluster of differentiation 22) helps to maintain B-cell homeostasis. This molecule act as an inhibitory coreceptor of the BCR (B cell receptor). CD22 is considered as a response regulator to control several aspects of B cell functions. Deficiency in CD22 or its pathways may contribute to autoimmunity.
Features and Benefits
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
Fujimoto M, et al.
Journal of Immunology, 176(2), 873-879 (2006)
High Resolution Crystal Structures of Siglec-7 INSIGHTS INTO LIGAND SPECIFICITY IN THE SIGLEC FAMILY.
Alphey MS, et al.
The Journal of Biological Chemistry, 278(5), 3372-3377 (2003)
Human CD22 inhibits murine B cell receptor activation in a human CD22 transgenic mouse model.
Bednar KJ, et al.
Journal of Immunology, 199(9), 3116-3128 (2017)
Molecular basis of human CD22 function and therapeutic targeting.
Ere?o-Orbea J, et al.
Nature Communications, 8(1), 764-764 (2017)
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