biological source
rabbit
recombinant
expressed in proprietary host
conjugate
unconjugated
antibody form
tissue culture supernatant
antibody product type
primary antibodies
clone
SP1, monoclonal
species reactivity
human (tested)
species reactivity (predicted by homology)
pig
technique(s)
immunoblotting: 1:25, immunohistochemistry: 1:200
isotype
IgG
UniProt accession no.
shipped in
wet ice
storage temp.
2-8°C
Gene Information
human ... ESR1(2099)
General description
The estrogen receptor 1 (ESR1) gene is mapped to human chromosome 6q25.1.
This antibody recognizes a protein of 67kDa, which is identified as estrogen receptor (ER). This antibody strongly stains the nucleus of epithelial cells in breast carcinomas. The ER is an important regulator of growth and differentiation in the mammary gland.
Immunogen
Synthetic peptide derived from C-terminus of human estrogen receptor alpha.
Biochem/physiol Actions
Estrogen receptor 1 (ESR1) is known to be a part of bone tissue phenotypes. The ESR1 gene encodes a steroid hormone receptor, which acts as a transcription factor. Estrogen activated ESR1 induces cell proliferation. Estrogen receptor participates in the pathogenesis of breast cancer.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Paul Stockhammer et al.
Pathology oncology research : POR, 27, 636088-636088 (2021-07-15)
Objective: Uterine carcinosarcoma (UCS) is a rare but highly aggressive malignancy with biphasic growth pattern. This morphology can be attributed to epithelial-mesenchymal transition (EMT) that often associates with tumor invasion and metastasis. Accordingly, we analyzed a novel patient-derived preclinical model
Estrogen Receptor Mediates the Radiosensitivity of Triple-Negative Breast Cancer Cells.
Chen X, et al.
Medical Science Monitor : International Medical Journal of Experimental and Clinical Research, 23, 2674-2674 (2017)
Association study of estrogen receptor alpha gene polymorphisms with bone mass assessed by quantitative ultrasound in young adults.
Correa-Rodriguez M, et al.
Rheumatology International, 37(8), 1281-1286 (2017)
Genome-wide association study identifies a novel breast cancer susceptibility locus at 6q25.1.
Zheng w, et al.
Nature Genetics, 41(3), 324-324 (2009)
Estrogen receptor α wields treatment-specific enhancers between morphologically similar endometrial tumors.
Droog M, et al.
Proceedings of the National Academy of Sciences of the USA, 114(8), E1316-E1325 (2017)
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